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Concise Review:One Stone for Multiple Birds:Generating Universally Compatible HumanEmbryonic Stem Cells
Dejin Zheng1; Xiaofang Wang2; Ren‐He Xu1,2
2016
Source PublicationSTEM CELLS
ISSN1066-5099
Volume34Issue:9Pages:2269–2275
Abstract

With ongoing clinical trials, human embryonic stem cells (hESCs) have shown substantial potential for regenerative medicine. However, due to the mismatch of human leukocyte antigens (HLAs) between hESC‐derived allografts and recipients, immunosuppressant regimens must be used to prevent immune rejection of the grafts. Considerable efforts have been devoted to overcoming this hurdle via the derivation and banking of human nuclear transfer ESCs, parthenogenetic ESCs, and induced pluripotent stem cells. However, ethical and safety concerns remain, hindering the application of these types of pluripotent cells. Other approaches have recently been explored to generate universally compatible hESCs through the silencing or deletion of HLAs or genes essential for HLA expression, including β‐2‐microglobulin and class‐II MHC transactivator, as well as the induction of immunosuppression via the ectopic expression of non‐classical HLAs (e.g., HLA‐E and ‐G), cytotoxic T lymphocyte antigen 4 fused with immunoglobulin, and programmed death ligand‐1. In this review, we introduce developments in this line of research and discuss strategies to reduce the tumorigenic concerns regarding hESCs, especially after they acquire the capability to escape immune surveillance. 

KeywordCell Transplantation Transplantation Tolerance Immunogenicity Immunosuppression Pluripotent Stem Cells
DOIhttps://doi.org/10.1002/stem.2407
Indexed BySCI
Language英语
WOS Research AreaCell Biology ; Biotechnology & Applied Microbiology ; Oncology ; Hematology
WOS SubjectCell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Oncology ; Cell Biology ; Hematology
WOS IDWOS:000383911700001
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorRen‐He Xu
Affiliation1.Faculty of Health Sciences,University of Macau, Taipa,Macau, China
2.ImStem Biotechnology, Inc,Farmington, Connecticut,USA
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Dejin Zheng,Xiaofang Wang,Ren‐He Xu. Concise Review:One Stone for Multiple Birds:Generating Universally Compatible HumanEmbryonic Stem Cells[J]. STEM CELLS,2016,34(9):2269–2275.
APA Dejin Zheng,Xiaofang Wang,&Ren‐He Xu.(2016).Concise Review:One Stone for Multiple Birds:Generating Universally Compatible HumanEmbryonic Stem Cells.STEM CELLS,34(9),2269–2275.
MLA Dejin Zheng,et al."Concise Review:One Stone for Multiple Birds:Generating Universally Compatible HumanEmbryonic Stem Cells".STEM CELLS 34.9(2016):2269–2275.
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