UM  > 健康科學學院
Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model
Li Yan1; Bin Jiang1; Yuyu Niu2; Hongxuan Wang1,3; Enqin Li1; Yaping Yan2; Huiyan Sun1,4; Yanchao Duan2; Shaohui Chang2; Guokai Chen1; Weizhi Ji2; Ren-He Xu1; Wei Si2
2018
Source PublicationCell Death Discovery
ISSN2058-7716
Volume4Issue:89
Abstract

Nonhuman primate experimental autoimmune encephalomyelitis (EAE) is a valuable model for multiple sclerosis, an inflammatory demyelinating disease in the central nervous system (CNS). Human embryonic stem cell-derived mesenchymal stem cells (EMSC) are effective in treating murine EAE. Yet, it remains unknown whether the EMSC efficacy is translatable to humans. Here we induced a primate EAE model in cynomolgus monkeys and delivered EMSC in spheres (EMSCsp) to preserve the cell viability during long-distance transportation. EMSCsp intrathecally injected into the CNS, remarkably reduced the clinical symptoms, brain lesions, and neuronal demyelination in the EAE monkeys during a 3-month observation. Whereas, symptoms in the vehicle control-injected EAE monkey remained and reduced slowly and MRI lesions in brain expanded. Moreover, EMSC could transdifferentiate into neural cells in vivo in the CNS of the treated animals. Supporting evidence demonstrated that EMSCsp cells cultured in cerebrospinal fluid from the EAE monkeys largely converted to neural cells with elevated expression of genes for neuronal markers, neurotrophic factors, and neuronal myelination. Thus, this study demonstrates that EMSCsp injected directly into the CNS, can attenuate the disease progression in the primate EAE model, highly encouraging for clinical translation.

DOIhttps://doi.org/10.1038/s41420-018-0091-0
Indexed By其他
Language英语
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionFaculty of Health Sciences
Co-First AuthorLi Yan
Corresponding AuthorRen-He Xu
Affiliation1.Faculty of Health Sciences, University of Macau, Taipa, Macau, China.
2.Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
3.Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
4.Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, Changchun, Jilin, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Li Yan,Bin Jiang,Yuyu Niu,et al. Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model[J]. Cell Death Discovery,2018,4(89).
APA Li Yan.,Bin Jiang.,Yuyu Niu.,Hongxuan Wang.,Enqin Li.,...&Wei Si.(2018).Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model.Cell Death Discovery,4(89).
MLA Li Yan,et al."Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model".Cell Death Discovery 4.89(2018).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li Yan]'s Articles
[Bin Jiang]'s Articles
[Yuyu Niu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li Yan]'s Articles
[Bin Jiang]'s Articles
[Yuyu Niu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li Yan]'s Articles
[Bin Jiang]'s Articles
[Yuyu Niu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.