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Predictive value of prospective memory for remission in first-episode schizophrenia
Zhou, FC1; Xiang, YT2,3; Wang, CY1; Dickerson, F4; Kreyenbuhl, J5,6; Ungvari, GS7,8; Au, RWC9; Zhou, JJ1; Zhou, Y1; Shum, D10,11; Man, D12; Lai, KYC13; Tang, WK14; Yu, X15; Chiu, HFK14
2014
Source PublicationPERSPECTIVES IN PSYCHIATRIC CARE
ISSN0031-5990
Volume50Issue:2Pages:102-110
Abstract

Purpose 

The study examined the rate of remission in individuals experiencing a first episode of schizophrenia(FES) in China and explored predictors of remission in the acute phase of the illness. 

Design and Methods 

Fifty-five FES patients were randomly treated with risperidone, olanzapine, or aripiprazole at therapeutic doses for 8 weeks, and their clinical profiles and cognition were assessed using standardized assessment instruments at entry and the end of the study. 

Findings 

Of the 55 patients, 30 (54.5%) remitted by the end of the 8-week study. In univariate analyses, shorter duration of untreated psychosis, higher scores on both the time-based prospective memory (TBPM) and event-based prospective memory tasks and the Hopkins Verbal Learning Test-revised, and less severe negative symptoms were significantly associated with remission. In stepwise multiple logistic regression analyses, only higher scores on the TBPM significantly predicted remission. Individuals having higher scores reflecting better TBPM at baseline were more likely to achieve remission after 8 weeks of optimized antipsychotic treatment. 

Practice Implications 

TPBM may be useful in helping clinicians identify those FES patients most likely to achieve a favorable treatment response.

KeywordFirst-episode Schizophrenia Acute Treatment Remission Prospective Memory
DOIhttp://dx.doi.org/10.1111/ppc.12027
Indexed BySCI
Language英语
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000333695600005
Fulltext Access
Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
2.Capital Med Univ, Beijing Anding Hosp, Mood Disorders Ctr, Beijing, Peoples R China
3.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
4.Sheppard Pratt, Stanley Res Program, Baltimore, MD USA
5.VISN 5 Mental Illness Res Educ & Clin Ctr MIRECC, Vet Adm Capitol Healthcare Network, Res Core, Baltimore, MD USA
6.Univ Maryland, Sch Med, Dept Psychiat, Div Res Serv, Baltimore, MD 21201 USA
7.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
8.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
9.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
10.Griffith Univ, Sch Appl Psychol, Brisbane, Qld 4111, Australia
11.Griffith Univ, Griffith Hlth Inst, Brisbane, Qld 4111, Australia
12.Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Hong Kong, Peoples R China
13.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
14.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
15.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zhou, FC,Xiang, YT,Wang, CY,et al. Predictive value of prospective memory for remission in first-episode schizophrenia[J]. PERSPECTIVES IN PSYCHIATRIC CARE,2014,50(2):102-110.
APA Zhou, FC.,Xiang, YT.,Wang, CY.,Dickerson, F.,Kreyenbuhl, J.,...&Chiu, HFK.(2014).Predictive value of prospective memory for remission in first-episode schizophrenia.PERSPECTIVES IN PSYCHIATRIC CARE,50(2),102-110.
MLA Zhou, FC,et al."Predictive value of prospective memory for remission in first-episode schizophrenia".PERSPECTIVES IN PSYCHIATRIC CARE 50.2(2014):102-110.
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