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Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis)
Goldenberg, Jonathan1,2; Cipriani, Vittoria1; Jackson, Timothy N. W.1,3; Arbuckle, Kevin4; Debono, Jordan1; Dashevsky, Daniel1; Panagides, Nadya1; Ikonomopoulou, Maria P.5,6,7; Koludarov, Ivan1; Li, Bin8; Santana, Renan Castro1; Nouwens, Amanda9; Jones, Alun10; Hay, Chris1; Dunstan, Nathan11; Allen, Luke11; Bush, Brian12; Miles, John J.5,13; Ge, Lilin14; Kwok, Hang Fai8; Fry, Bryan G.1
2018-02
Source PublicationCOMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
ISSN1532-0456
Volume205Pages:53-61
Abstract

Pseudechis (black snakes) is an Australasian elapid snake genus that inhabits much of mainland Australia, with two representatives confined to Papua New Guinea. The present study is the first to analyse the venom of all 9 described Pseudechis species (plus one undescribed species) to investigate the evolution of venom composition and functional activity. Proteomic results demonstrated that the typical Pseudechis venom profile is dominated by phospholipase A, toxins. Strong cytotoxicity was the dominant function for most species. P. porphyriacus, the most basal member of the genus, also exhibited the most divergent venom composition, being the only species with appreciable amounts of procoagulant toxins. The relatively high presence of factor Xa recovered in P. porphyriacus venom may be related to a predominantly amphibian diet. Results of this study provide important insights to guide future ecological and toxinological investigations.

KeywordVenom Evolution Pseudechis Black Snakes Diet Toxins Proteomic Enzymology Oxyuraninae Pla(2)
DOI10.1016/j.cbpc.2018.01.001
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
WOS IDWOS:000427217800007
PublisherELSEVIER SCIENCE INC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorKwok, Hang Fai; Fry, Bryan G.
Affiliation1.Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia
2.Evolution and Optics of Nanostructures Group, Department of Biology, University of Ghent, Ledeganckstraat 35, Ghent 9000, Belgium
3.Australian Venom Research Unit, Department of Pharmacology, University of Melbourne, Parkville, VIC 3000, Australia
4.Department of Biosciences, College of Science, Swansea University, Swansea SA2, 8PP, UK
5.QIMR Berghofer Institute of Medical Research, Herston, QLD 4049, Australia
6.School of Medicine, The University of Queensland, Herston, QLD 4002, Australia
7.Madrid Institute for Advanced Studies (IMDEA) in Food, CEI UAM+CSIC, Madrid 28049, Spain
8.Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, China
9.School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia
10.Institute for Molecular Biosciences, University of Queensland, Slt Lucia, QLD 4072, Australia
11.Venom Supplies, Tanunda, SA 5352, Australia
12.Snakes Harmful & Harmless, 9 Birch Place, Stoneville, WA 6081, Australia
13.Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD 4878, Australia
14.School of Pharmacy, Nanjing University of Chinese Medicine, Qixia District, Nanjing, China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Goldenberg, Jonathan,Cipriani, Vittoria,Jackson, Timothy N. W.,et al. Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis)[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2018,205:53-61.
APA Goldenberg, Jonathan.,Cipriani, Vittoria.,Jackson, Timothy N. W..,Arbuckle, Kevin.,Debono, Jordan.,...&Fry, Bryan G..(2018).Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis).COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,205,53-61.
MLA Goldenberg, Jonathan,et al."Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis)".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 205(2018):53-61.
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