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Role of Reactive Oxygen Species in Tumor Necrosis Factor-alpha Induced Endothelial Dysfunction
Xiuping Chen1,2; Bradley T. Andresen1,3; Michael Hill4; Jing Zhang1,2; Frank Booth2,5; Cuihua Zhang1,2
2008-11
Source PublicationCurrent Hypertension Reviews
ISSN1573-4021
Volume4Issue:4Pages:245-255
Abstract

Endothelial cell injury and dysfunction are the major triggers of pathophysiological processes leading to cardiovascular disease. Endothelial dysfunction (ED) has been implicated in atherosclerosis, hypertension, coronary artery disease, vascular complications of diabetes, chronic renal failure, insulin resistance and hypercholesterolemia. Although now recognized as a class of physiological second messengers, reactive oxygen species (ROS) are important mediators in cellular injury, specifically, as a factor in endothelial cell damage. Uncontrolled ROS production and/or decreased antioxidant activity results in a deleterious state referred to as ‘oxidative stress’. A candidate factor in causing ROS production in endothelial cells is tumor necrosis factor alpha (TNF-), a pleiotropic inflammatory cytokine. TNF- has been shown to both be secreted by endothelial cells and to induce intracellular ROS formation. These observations provide a potential mechanism by which TNF- may activate and injure endothelial cells resulting in ED. In this review, we focus on the relationship between intracellular ROS formation and ED in endothelial cells or blood vessels exposed to TNF- to provide insight into the role of this important cytokine in cardiovascular disease.

KeywordCardiovascular Disease Endothelial Cell Inflammation Mitochondria Nad(p)h Oxidase Nitric Oxide
Language英语
Fulltext Access
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorCuihua Zhang
Affiliation1.Departments of Internal Medicine
2.Medical Pharmacology & Physiology and Nutritional Sciences, Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, MO 65211, USA
3.Harry S. Truman VA Medical Center, Columbia, MO 65201, USA
4.Department of Medical Pharmacology & Physiology, Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, MO 65211, USA
5.Department of Biomedical Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA
Recommended Citation
GB/T 7714
Xiuping Chen,Bradley T. Andresen,Michael Hill,et al. Role of Reactive Oxygen Species in Tumor Necrosis Factor-alpha Induced Endothelial Dysfunction[J]. Current Hypertension Reviews,2008,4(4):245-255.
APA Xiuping Chen,Bradley T. Andresen,Michael Hill,Jing Zhang,Frank Booth,&Cuihua Zhang.(2008).Role of Reactive Oxygen Species in Tumor Necrosis Factor-alpha Induced Endothelial Dysfunction.Current Hypertension Reviews,4(4),245-255.
MLA Xiuping Chen,et al."Role of Reactive Oxygen Species in Tumor Necrosis Factor-alpha Induced Endothelial Dysfunction".Current Hypertension Reviews 4.4(2008):245-255.
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