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Role of TNF-α in vascular dysfunction
Hanrui Zhang1,2,3,4; Yoonjung Park1,2,3,4; Junxi Wu1,2,3,4; Xiu ping Chen1,2,3,4; Sewon Lee1,2,3,4; Jiyeon Yang1,2,3,4; Kevin C. Dellsperger1,2; Cuihua Zhang1,2,3,4
2009-02
Source PublicationClinical Science
ISSN0143-5221
Volume116Issue:3Pages:219-230
Abstract

Healthy vascular function is primarily regulated by several factors including EDRF (endotheliumdependent relaxing factor), EDCF (endothelium-dependent contracting factor) and EDHF (endothelium-dependent hyperpolarizing factor). Vascular dysfunction or injury induced by aging, smoking, inflammation, trauma, hyperlipidaemia and hyperglycaemia are among a myriad of risk factors that may contribute to the pathogenesis of many cardiovascular diseases, such as hypertension, diabetes and atherosclerosis. However, the exact mechanisms underlying the impaired vascular activity remain unresolved and there is no current scientific consensus. Accumulating evidence suggests that the inflammatory cytokine TNF (tumour necrosis factor)-α plays a pivotal role in the disruption of macrovascular and microvascular circulation both in vivo and in vitro. AGEs (advanced glycation end-products)/RAGE (receptor for AGEs), LOX-1 [lectin-like oxidized low-density lipoprotein receptor-1) and NF-κB (nuclear factor κB) signalling play key roles in TNF-α expression through an increase in circulating and/or local vascular TNF-α production. The increase in TNF-α expression induces the production of ROS (reactive oxygen species), resulting in endothelial dysfunction in many pathophysiological conditions. Lipid metabolism, dietary supplements and physical activity affect TNF-α expression. The interaction between TNF-α and stem cells is also important in terms of vascular repair or regeneration. Careful scrutiny of these factors may help elucidate the mechanisms that induce vascular dysfunction. The focus of the present review is to summarize recent evidence showing the role of TNF-α in vascular dysfunction in cardiovascular disease. We believe these findings may prompt new directions for targeting inflammation in future therapies.

KeywordInflammation Macrovascular Circulation Microvascular Circulation Nitric Oxide Reactive Oxygen Species (Ros) Tumour Necrosis Factor-α (Tnf-α)
DOIhttp://dx.doi.org/10.1042/CS20080196
Indexed BySCI
Language英语
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000263044600004
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Cited Times [WOS]:336   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorCuihua Zhang
Affiliation1.Department of Internal Medicine, University of Missouri, Columbia, MO 65211, U.S.A.
2.Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, U.S.A.
3.Department of Nutritional Sciences, University of Missouri, Columbia, MO 65211, U.S.A.
4.Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, U.S.A.
Recommended Citation
GB/T 7714
Hanrui Zhang,Yoonjung Park,Junxi Wu,et al. Role of TNF-α in vascular dysfunction[J]. Clinical Science,2009,116(3):219-230.
APA Hanrui Zhang.,Yoonjung Park.,Junxi Wu.,Xiu ping Chen.,Sewon Lee.,...&Cuihua Zhang.(2009).Role of TNF-α in vascular dysfunction.Clinical Science,116(3),219-230.
MLA Hanrui Zhang,et al."Role of TNF-α in vascular dysfunction".Clinical Science 116.3(2009):219-230.
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