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Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: predicting Alzheimer’s disease
Yin Tian1; Zechao Ding1; KinYip Tam3; Zhongyan Wang1; Huiling Zhang1; Dechun Zhao1; Yi Zhao1; Wei Xu1; Shuxing Zheng2
2015
Source PublicationADMET & DMPK
ISSN1848-7718
Volume3Issue:3Pages:274-280
Abstract

Resting-state functional magnetic resonance imaging was utilized to measure the amplitude low frequency fluctuations (ALFF) in human subjects with Alzheimer’s disease (AD) and normal control (NC). Two specific frequency bands (Slow5: 0.01-0.027 Hz and Slow4: 0.027-0.073 Hz) were analysed in the main cognitive control related four subregions of the right ventral lateral prefrontal cortex (VLPFC), i.e. IFJ, posteriorVLPFC, mid-VLPFC, and anterior-VLPFC. Differences in ALFF values between the AD and the NC group were found throughout the subregions of the right VLPFC. Compared to normal control group, decreased ALFF values were observed in AD patients in the IFJ (in two given frequency bands), and the mid-VLPFC (in Slow5). In contrast, increased ALFF valued were observed in AD patients in the posterior- and anteriorVLPFC (in both Slow5 and Slow4), and also in the mid-VLPFC in Slow4. Moreover, significant ALFF differences between the IFJ and three other subregions of the right VLPFC were found. Furthermore, ALFF values in the right VLPFC showed significant correlations with the time course of disease. Taken together, our findings suggest that AD patients have largely abnormalities in intrinsic neural oscillations which are in line with the AD pathophysiology, and further reveal that the abnormalities are dependent on specific frequency bands. Thus, frequency-domain analyses of the ALFF may provide a useful tool to investigate the AD pathophysiology.

KeywordAd Alff Vlpfc Rs-fmri Top-down Modulation
DOIhttp://doi.org/10.5599/admet.3.3.208
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000447335900011
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorYin Tian
Affiliation1.Bio-information College, ChongQing University of Posts and Telecommunications, ChongQing 400065, China
2.Colleg of Computer Science and Technology, ChongQing University of Posts and Telecommunications, ChongQing 400065, China
3.Faculty of Health Sciences, University of Macau, Macau, China
Recommended Citation
GB/T 7714
Yin Tian,Zechao Ding,KinYip Tam,et al. Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: predicting Alzheimer’s disease[J]. ADMET & DMPK,2015,3(3):274-280.
APA Yin Tian.,Zechao Ding.,KinYip Tam.,Zhongyan Wang.,Huiling Zhang.,...&Shuxing Zheng.(2015).Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: predicting Alzheimer’s disease.ADMET & DMPK,3(3),274-280.
MLA Yin Tian,et al."Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: predicting Alzheimer’s disease".ADMET & DMPK 3.3(2015):274-280.
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