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Animal models for Alzheimer’sdisease: a focused review of transgenic rodent models and behavioral assessment methods
Xiaoli Wu; Jing Li; Wei Zhou; Kin Tam
2015
Source PublicationADMET & DMPK
ISSN1848-7718
Volume3Issue:3Pages:242-253
Abstract

With the increased morbidity and unclear etiology of Alzheimer’s disease (AD), there is an urgent need to put more effort to investigate the causes of the disease and develop novel drug to stop or reverse the disease progression. Transgenic rodent models mimicking different types of AD-like pathologies are essential resources to discover potential drug targets and study the mechanisms of drug actions. The common symptom of AD is the cognitive deficits. The ultimate readout for any interventions should be evaluated by the test of learning and memory. Although a multiply number of rodent models and behavioural assessment methods have been widely utilized in mechanism studies and screening of novel drug candidates, large variability still exists in the methodologies, especially in terms of how the rodent models are being utilized. To select suitable and valid models for supporting AD research, it is important to understand the characteristics and applicability of the rodent models and behavioural assessment methods. This review seeks to summarize and discuss the pathological feature of some transgenic rodent models that are commonly used in AD research (e.g. APP, PS1/2 and tau gene mutations). Moreover, thecharacteristics and applicability of some behavioural assessment methods (e.g. Morris water maze and radial arm water maze) will be summarized. Finally, we will discuss the applicability of these models and methods in AD research.

KeywordNeurodegeneration Transgenic Mice Behavioural Alteration Morris Water Maze Radial Arm Water Maze Cognitive Impairmen
DOIhttp://doi.org/10.5599/admet.3.3.195
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000447335900008
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorKin Tam
AffiliationFaculty of Health Science, University of Macau, Macau, China
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Xiaoli Wu,Jing Li,Wei Zhou,et al. Animal models for Alzheimer’sdisease: a focused review of transgenic rodent models and behavioral assessment methods[J]. ADMET & DMPK,2015,3(3):242-253.
APA Xiaoli Wu,Jing Li,Wei Zhou,&Kin Tam.(2015).Animal models for Alzheimer’sdisease: a focused review of transgenic rodent models and behavioral assessment methods.ADMET & DMPK,3(3),242-253.
MLA Xiaoli Wu,et al."Animal models for Alzheimer’sdisease: a focused review of transgenic rodent models and behavioral assessment methods".ADMET & DMPK 3.3(2015):242-253.
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