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Natural autophagy regulators in cancer therapy: a review
Qian Ding; Jiaolin Bao; Wenwen Zhao; Yangyang Hu; Jinjian Lu; Xiuping Chen
2015-02
Source PublicationPhytochemistry Reviews
ISSN1568-7767
Volume14Issue:1Pages:137-154
Abstract

Autophagy is a complicated self-eating response of cells to external or internal stimuli. This process involves cellular degradation through the lysosomes of dysfunctional or unnecessary cellular components or organelles to maintain basic energy levels. This nonapoptotic programmed cell death, similar to other main phenomena of cell biology such as apoptosis and differentiation, has been implicated in the pathogenesis of a series of disorders, such as neurodegenerative diseases, cardiovascular diseases, and especially in cancer. Increasing evidence has suggested that the autophagy pathways may provide potential targets for cancer intervention, although their precise roles in cancer initiation and progression remain controversial. Natural products are very important sources of chemotherapeutics agents. Regulation of autophagy could be an important mechanism contributing to the beneficial effect of quite a few natural products. Herein, we briefly introduce the characteristics and roles of autophagy in cancer and systematically summarize the natural autophagy regulators, with emphasis on apigenin, berberine, beta-elemene, capsaicin, curcumin, genistein, kaempferol, oridonin, paclitaxel, quercetin, resveratrol, silybin, triptolide, and ursolic acid, with the aim to provide information for novel avenues on cancer therapies based on autophagy.

KeywordAutophagy Cancer Natural Products Drug Discovery
DOIhttps://dx.doi.org/10.1007/s11101-014-9339-3
Language英语
WOS Research AreaPlant Sciences
WOS SubjectPlant Sciences
WOS IDWOS:000350895300007
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXiuping Chen
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical SciencesUniversity of MacauTaipaChina
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Qian Ding,Jiaolin Bao,Wenwen Zhao,et al. Natural autophagy regulators in cancer therapy: a review[J]. Phytochemistry Reviews,2015,14(1):137-154.
APA Qian Ding,Jiaolin Bao,Wenwen Zhao,Yangyang Hu,Jinjian Lu,&Xiuping Chen.(2015).Natural autophagy regulators in cancer therapy: a review.Phytochemistry Reviews,14(1),137-154.
MLA Qian Ding,et al."Natural autophagy regulators in cancer therapy: a review".Phytochemistry Reviews 14.1(2015):137-154.
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