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A Systematic Review of the Anticancer Properties of Compounds Isolated from Licorice (Gancao)
Tang ZH1; Li T1; Tong YG2; Chen XJ1; Chen XP1; Wang YT1; Lu JJ1
2015-12
Source PublicationPlanta Medica
ISSN0032‑0943
Volume81Issue:18Pages:1670-1687
Abstract

Licorice (Gancao in Chinese) has been used worldwide as a botanical source in medicine and as a sweetening agent in food products for thousands of years. Triterpene saponins and flavonoids are its main ingredients that exhibit a variety of biological activities, including hepatoprotective, antiulcer, anti-inflammatory, antiviral and anticancer effects among others. This review attempts to summarize the current knowledge on the anticancer properties and mechanisms of the compounds isolated from licorice and obtain new insights for further research and development of licorice. A broad spectrum of in vitro and in vivo studies have recently demonstrated that the mixed extracts and purified compounds from licorice exhibit evident anticancer properties by inhibition of proliferation, induction of cell cycle arrest, apoptosis, autophagy, differentiation, suppression of metastasis, angiogenesis, and sensitization of chemotherapy or radiotherapy. A combined treatment of licorice compounds and clinical chemotherapy drugs remarkably enhances anticancer effects and reduces the side effects of chemotherapeutics. Furthermore, glycyrrhizic acid and glycyrrhetinic acid in licorice have been indicated to present obvious liver-targeting effects in targeted drug delivery systems for hepatocellular carcinoma treatment.

KeywordGlycyrrhiza Glabra Leguminosae Licorice Anticancer Mechanism Triterpenoids Flavonoids
DOIhttp://dx.doi.org/10.1055/s-0035-1558227
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000366946600004
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Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLu JJ
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.Department of Medicine, Cedars-Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles, CA, USA
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Tang ZH,Li T,Tong YG,et al. A Systematic Review of the Anticancer Properties of Compounds Isolated from Licorice (Gancao)[J]. Planta Medica,2015,81(18):1670-1687.
APA Tang ZH.,Li T.,Tong YG.,Chen XJ.,Chen XP.,...&Lu JJ.(2015).A Systematic Review of the Anticancer Properties of Compounds Isolated from Licorice (Gancao).Planta Medica,81(18),1670-1687.
MLA Tang ZH,et al."A Systematic Review of the Anticancer Properties of Compounds Isolated from Licorice (Gancao)".Planta Medica 81.18(2015):1670-1687.
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