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The human Nox4: gene, structure, physiological function and pathological significance
Shuhui Guo; Xiuping Chen
2015-12
Source PublicationJournal of Drug Targeting
ISSN1061-186X
Volume23Issue:10Pages:888-896
Abstract

Increased generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a variety of diseases such as cardiovascular diseases and cancer. NADPH oxidase (Nox), a multicomponent enzyme, has been identified as one of the key sources of ROS. Nox4, one of the seven members of Nox family (Nox1, Nox2, Nox3, Nox4, Nox5, Duox1 and Duox2), has been extensively investigated in recent years. Its unique structures result in theconstitutive generation of hydrogen peroxide (H2O2) as the main product. As a key oxygen sensor, Nox4-derived H2O2 plays diverse roles in cell proliferation, migration and death. Increased expression of Nox4 in cancer has been observed, which participates in metastasis, angiogenesis and apoptosis. Expression of Nox4 in endothelial cells actively mediated endothelial activation, dysfunction and injury, which contributes to thedevelopment of atherosclerosis, hypertension, cardiac hypertrophy and among others. This article explores the experimental studies related to thegene, structure, physiological function and pathological significance of Nox4. As Nox4 might serve as a potential target for the therapy of cardiovascular diseases and cancer, the Nox4 inhibitor is also discussed in this article.

KeywordCancer Cardiovascular Diseases Hydrogen Peroxides Nox4 Ros
DOIhttps://dx.doi.org/10.3109/1061186X.2015.1036276
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000371397000002
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Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXiuping Chen
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Shuhui Guo,Xiuping Chen. The human Nox4: gene, structure, physiological function and pathological significance[J]. Journal of Drug Targeting,2015,23(10):888-896.
APA Shuhui Guo,&Xiuping Chen.(2015).The human Nox4: gene, structure, physiological function and pathological significance.Journal of Drug Targeting,23(10),888-896.
MLA Shuhui Guo,et al."The human Nox4: gene, structure, physiological function and pathological significance".Journal of Drug Targeting 23.10(2015):888-896.
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