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A tutorial review for employing enzymes for the construction of G-quadruplex-based sensing platforms
Dik-Lung Ma1; Wanhe Wang1; Zhifeng Mao1; Chao Yang2; Xiu-Ping Chen2; Jin-Jian Lu2; Quan-Bin Han3; Chung-Hang Leung2
2016-03-24
Source PublicationAnalytica Chimica Acta
ISSN0003-2670
Volume913Pages:41-54
Abstract

With rapid advances in the field of DNA chemistry, nucleic acids and DNA-modifying enzymes have recently emerged as versatile components for the construction of oligonucleotide-based sensors. Meanwhile, the G-quadruplex motif has been widely employed for the development of DNA-based assays due to its diverse structural variety. In this tutorial, we introduce the principles of G-quadruplex-based sensing and the use of DNA-modifying enzymes for sensor platform development. We also highlight recent studies of the application of DNA-modifying enzymes for the development of G-quadruplex-based luminescent detection platforms with a view towards how those enzymes play an important role in sensitivity enhancement.

KeywordOligonucleotide-based Sensor G-quadruplex Enzyme Sensor Construction
DOIhttps://doi.org/10.1016/j.aca.2016.01.043
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000371221700003
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorDik-Lung Ma; Chung-Hang Leung
Affiliation1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
3.School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Dik-Lung Ma,Wanhe Wang,Zhifeng Mao,et al. A tutorial review for employing enzymes for the construction of G-quadruplex-based sensing platforms[J]. Analytica Chimica Acta,2016,913:41-54.
APA Dik-Lung Ma.,Wanhe Wang.,Zhifeng Mao.,Chao Yang.,Xiu-Ping Chen.,...&Chung-Hang Leung.(2016).A tutorial review for employing enzymes for the construction of G-quadruplex-based sensing platforms.Analytica Chimica Acta,913,41-54.
MLA Dik-Lung Ma,et al."A tutorial review for employing enzymes for the construction of G-quadruplex-based sensing platforms".Analytica Chimica Acta 913(2016):41-54.
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