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Demographic and clinical differences between early- and late-onset bipolar disorders in a multicenter study in China
Zhang, L1,2,3,4; Yang, HC5; Xu, XF6; Fang, YR7; Yu, X8,9,10; Tan, QR11; Li, HC12; Ungvari, GS13,14; Ng, CH15; Wang, G1,2,3; Xiang, YT4
2016
Source PublicationPSYCHIATRY RESEARCH
ISSN0165-1781
Volume246Pages:688-691
Abstract

Little is known about the demographic and clinical differences between early-onset (EOB) and late-onset bipolar disorders (LOB) in Chinese patients. This multi-center study examined the demographicand clinical characteristics of EOB (521 years) and LOB ( > 21 years) in China. A consecutively recruited sample of 555 patients with bipolar disorder (BD) from 7 psychiatric hospitals and general hospital psychiatric units across China was examined. Patients' demographic and clinical characteristics were collected using a standardized protocol and data collection procedure. There were 181 (34.8%) patients with EOB and 339 (65.2%) with LOB. Univariate analyses revealed that compared to the LOB group, the EOB group were more likely to be older, unemployed, have a longer illness duration, have BD-I and misdiagnosed as schizophrenia but were less likely to be misdiagnosed as major depressive disorder and receiving antidepressants. Multivariate analyses revealed that unemployment and longer duration of illness were independently associated with EOB. The clinical differences betweenearly-onset and late-onset BD patients in China were largely consistent with those found in Western countries. Early-onset BD appear to be associated with poorer outcomes. Prospective studies examining the long-term outcomes in relation to age-at-onset are needed.

KeywordBipolar Disorder China Late Onset Early Onset
DOIhttp://dx.doi.org/10.1016/j.psychres.2016.10.063
Indexed BySCI
Language英语
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000390968300109
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
2.Capital Med Univ, Beijing Anding Hosp, Ctr Depress, Beijing Inst Brain Disorders, Beijing, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Mood Disorders Ctr, Beijing, Peoples R China
4.Univ Macau, Fac Hlth Sci, Unit Psychiat, Macau, Peoples R China
5.Shenzhen Mental Hlth Ctr, Div Mood Disorders, Shenzhen, Guangdong, Peoples R China
6.Kunming Med Univ, Affiliated Hosp 1, Dept Psychiat, Kunming, Yunnan Province, Peoples R China
7.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Div Mood Disorders, Shanghai, Peoples R China
8.Peking Univ, Inst Mental Hlth, Hosp 6, Beijing, Peoples R China
9.Peking Univ, Minist Hlth, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
10.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
11.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian, Shaanxi Provinc, Peoples R China
12.Zhejiang Univ, Coll Med, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China
13.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
14.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA, Australia
15.Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Zhang, L,Yang, HC,Xu, XF,et al. Demographic and clinical differences between early- and late-onset bipolar disorders in a multicenter study in China[J]. PSYCHIATRY RESEARCH,2016,246:688-691.
APA Zhang, L.,Yang, HC.,Xu, XF.,Fang, YR.,Yu, X.,...&Xiang, YT.(2016).Demographic and clinical differences between early- and late-onset bipolar disorders in a multicenter study in China.PSYCHIATRY RESEARCH,246,688-691.
MLA Zhang, L,et al."Demographic and clinical differences between early- and late-onset bipolar disorders in a multicenter study in China".PSYCHIATRY RESEARCH 246(2016):688-691.
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