UM  > 健康科學學院
Inter-MAR Association Contributes to Transcriptionally Active Looping Events in Human β-globin Gene Cluster
Li Wang1,2; Li-Jun Di1,2; Xiang Lv1,2; Wei Zheng1,2; Zheng Xue1,2; Zhi-Chen Guo1,2; De-Pei Liu1,2; Chi-Chuan Liang1,2
2009
Source PublicationPLoS ONE
ISSN1932-6203
Volume4Issue:2
Abstract

Matrix attachment regions (MARs) are important in chromatin organization and gene regulation. Although it is known that there are a number of MAR elements in the b-globin gene cluster, it is unclear that how these MAR elements are involved in regulating b-globin genes expression. Here, we report the identification of a new MAR element at the LCR(locus control region) of human b-globin gene cluster and the detection of the inter-MAR association within the b-globin gene cluster. Also, we demonstrate that SATB1, a protein factor that has been implicated in the formation of network like higher order chromatin structures at some gene loci, takes part in b-globin specific inter-MAR association through binding the specific MARs. Knocking down of SATB1 obviously reduces the binding of SATB1 to the MARs and diminishes the frequency of the inter-MAR association. As a result, the ACH establishment and the a-like globin genes and b-like globin genes expressions are affected either. In summary, our results suggest that SATB1 is a regulatory factor of hemoglobin genes, especially the early differentiation genes at least through affecting the higher order chromatin structure.

DOIhttps://doi.org/10.1371/journal.pone.0004629
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000265487800011
Fulltext Access
Citation statistics
Cited Times [WOS]:22   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100037, Peoples R China
2.PUMC, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Li Wang,Li-Jun Di,Xiang Lv,et al. Inter-MAR Association Contributes to Transcriptionally Active Looping Events in Human β-globin Gene Cluster[J]. PLoS ONE,2009,4(2).
APA Li Wang.,Li-Jun Di.,Xiang Lv.,Wei Zheng.,Zheng Xue.,...&Chi-Chuan Liang.(2009).Inter-MAR Association Contributes to Transcriptionally Active Looping Events in Human β-globin Gene Cluster.PLoS ONE,4(2).
MLA Li Wang,et al."Inter-MAR Association Contributes to Transcriptionally Active Looping Events in Human β-globin Gene Cluster".PLoS ONE 4.2(2009).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li Wang]'s Articles
[Li-Jun Di]'s Articles
[Xiang Lv]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li Wang]'s Articles
[Li-Jun Di]'s Articles
[Xiang Lv]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li Wang]'s Articles
[Li-Jun Di]'s Articles
[Xiang Lv]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.