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Illustration of SSMD, z score, SSMD*, z* score, and t statistic for hit selection in RNAi high-throughput screens
Zhang X.D.
2011-08-01
Source PublicationJournal of Biomolecular Screening
ISSN10870571 1552454X
Volume16Issue:7Pages:775-785
AbstractHit selection is the ultimate goal in many high-throughput screens. Various analytic methods are available for this purpose. Some commonly used ones are z score, z* score, strictly standardized mean difference (SSMD), SSMD*, and t statistic. It is critical to know how to use them correctly because the misusage of them can readily produce misleading results. Here, the author presents basic concepts, elaborates their commonality and difference, describes some common misusage that people should avoid, and uses simulated simple examples to illustrate how to use them correctly. © 2011 Society for Laboratory Automation and Screening.
Keywordhigh-throughput screening SSMD SSMD* t statistic z score z* score
DOI10.1177/1087057111405851
URLView the original
Language英語
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Cited Times [WOS]:81   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationMerck Research Laboratories
Recommended Citation
GB/T 7714
Zhang X.D.. Illustration of SSMD, z score, SSMD*, z* score, and t statistic for hit selection in RNAi high-throughput screens[J]. Journal of Biomolecular Screening,2011,16(7):775-785.
APA Zhang X.D..(2011).Illustration of SSMD, z score, SSMD*, z* score, and t statistic for hit selection in RNAi high-throughput screens.Journal of Biomolecular Screening,16(7),775-785.
MLA Zhang X.D.."Illustration of SSMD, z score, SSMD*, z* score, and t statistic for hit selection in RNAi high-throughput screens".Journal of Biomolecular Screening 16.7(2011):775-785.
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