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An effective analytic method for detecting tissue-specific genes in RNA-seq experiments
Zhao G.4; Li Q.3; Wang I.-M.1; Liu X.2; Fang X.4; Zhang X.D.1
2015-11-01
Source PublicationPharmacogenomics
ISSN17448042 14622416
Volume16Issue:16Pages:1769-1779
AbstractAim: To develop an analytic method for identifying tissue-specific (TS) genes from RNA-seq data. Materials & methods: Based on a negative binomial distribution, we develop a statistical method containing consecutive procedures incorporating data variability from replicates in each tissue. Results: Simulations show that our approach can effectively identify at least 94% of the truly TS genes if the sample size is 3 and at least 84% of the TS genes detected by our method are truly TS genes. We illustrated the utility of our method in an in-house RNA-seq project and produced sensible results. Conclusion: Our approach not only directly works on discrete data but also naturally incorporates data variability. It works effectively for detecting TS genes.
Keywordconsecutive procedures generalization of Tukey's test next-generation sequencing RNA-Seq tissue-specific gene
DOI10.2217/pgs.15.118
URLView the original
Language英語
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Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Merck Research Laboratories
2.Scientific Informatics
3.BARDS
4.Peking University
Recommended Citation
GB/T 7714
Zhao G.,Li Q.,Wang I.-M.,et al. An effective analytic method for detecting tissue-specific genes in RNA-seq experiments[J]. Pharmacogenomics,2015,16(16):1769-1779.
APA Zhao G.,Li Q.,Wang I.-M.,Liu X.,Fang X.,&Zhang X.D..(2015).An effective analytic method for detecting tissue-specific genes in RNA-seq experiments.Pharmacogenomics,16(16),1769-1779.
MLA Zhao G.,et al."An effective analytic method for detecting tissue-specific genes in RNA-seq experiments".Pharmacogenomics 16.16(2015):1769-1779.
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