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Model development and numerical simulation of electric-stimulus-responsive hydrogels subject to an externally applied electric field
Hua Li1; Z. Yuan1; K.Y. Lam1; H.P. Lee1; Jun Chen1; Justin Hanes2; Jie Fu2
2004-04-15
Source PublicationBiosensors and Bioelectronics
ISSN0956-5663
Volume19Issue:9Pages:1097-1107
Abstract

Based on a multi-phasic mixture theory with consideration of ionic diffusion and convection, a multi-physic model, called the multi-effectcoupling electric-stimulus (MECe) model, is developed for simulation of responsive behavior of the electric-sensitive hydrogels when they are immersed into a bathing solution subject to an externally applied electric field. In the developed model, with chemo-electro-mechanical coupling effects, the convection–diffusion equations for concentration distribution of diffusive ions incorporate the influence of electric potential. The electroneutrality condition is replaced by the Poisson equation for distribution of electric potential. The steady and transient analyses of hydrogel deformation are easily carried out by the continuity and momentum equations of the mixture phase. Further, the computational domain of the present model covers both the hydrogel and the surrounding solution. In order to solve the present mathematical model consisting of multi-field coupled nonlinear partial differential governing equations, a hierarchical iteration technique is proposed and a meshless Hermite–Cloud method (HCM) is employed. The steady-state simulation of the electric-stimulus responsive hydrogel is numerically conducted when it is subjected to an externally applied electric field. The hydrogel deformation and the ionic concentrations as well as electric potentials of both the hydrogel and external solution are investigated. The parameter influences on the swelling behaviors of the hydrogel are also discussed in detail. The simulating results are in good agreement with the experimental data and they validate the presently developed model.

KeywordElectric-stimulus Responsive Hydrogels Multiphasic Mixture Theory Mathematical Mode Diffusion Convection Biomems Meshless Method
DOIhttp://doi.org/10.1016/j.bios.2003.10.004
Indexed BySCI
Language英语
WOS Research AreaBiophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
WOS SubjectBiophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
WOS IDWOS:000220276100017
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Cited Times [WOS]:64   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorHua Li
Affiliation1.Institute of High Performance Computing, National University of Singapore, 1 Science Park Road, #01-01 The Capricorn, Singapore Science Park II, Singapore 117528, Singapore
2.Department of Chemical Engineering, The Johns Hopkins University, 3400 N. Charles Street, 221 MD Hall, Baltimore, MD 21218, USA
Recommended Citation
GB/T 7714
Hua Li,Z. Yuan,K.Y. Lam,et al. Model development and numerical simulation of electric-stimulus-responsive hydrogels subject to an externally applied electric field[J]. Biosensors and Bioelectronics,2004,19(9):1097-1107.
APA Hua Li.,Z. Yuan.,K.Y. Lam.,H.P. Lee.,Jun Chen.,...&Jie Fu.(2004).Model development and numerical simulation of electric-stimulus-responsive hydrogels subject to an externally applied electric field.Biosensors and Bioelectronics,19(9),1097-1107.
MLA Hua Li,et al."Model development and numerical simulation of electric-stimulus-responsive hydrogels subject to an externally applied electric field".Biosensors and Bioelectronics 19.9(2004):1097-1107.
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