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Application of nano-and micro-particles on the topical therapy of skin-related immune disorders
Sun L.3; Liu Z.3; Cun D.2; Tong H.H.Y.1; Zheng Y.3
2015-06-01
Source PublicationCurrent Pharmaceutical Design
ISSN18734286 13816128
Volume21Issue:19Pages:2643-2667
Abstract

Several immune disorders may occur in the skin, such as psoriasis, atopic dermatitis and vitiligo. As the largest organ in the human body, skin provides a unique and non-invasive platform to deliver active pharmaceutical ingredients into superficial lesions or even circulations. In recent years, novel pharmaceutical particles were applied in the topical treatment for skin-related immune disorders to keep the stability, improve the bioactivity, as well as reduce the toxicity of APIs, or even provide a targeting property for the agents. As the pathogenesis of these diseases is increasingly highlighted, the target site and function of topical delivery of particles become more clear and specific. Therefore, diversified surface engineering of vehicles has gradually gained more attention. Appropriate size, charge and surface modification of API-loaded particles can bring out a favorable effect for skin disorders. In this review, comparison of normal and pathological skin structure, penetration route of various drug particles, nano- and micro- particles applied for skin-related immune disorders are summarized. In-vitro and in-vivo evaluation methods for topical therapy of immune disorders will be discussed. Moreover, recent applications of particles loaded with active ingredients from herbal medicines or biological agents for skin immune disorders are also highlighted.

KeywordAtopic Dermatitis Immune Disorders Particles Psoriasis Skin Topical
DOI10.2174/1381612821666150416100516
URLView the original
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000354609400008
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被引频次[WOS]:5   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Affiliation1.Macao Polytechnic Institute
2.Shenyang Pharmaceutical University
3.Universidade de Macau
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GB/T 7714
Sun L.,Liu Z.,Cun D.,et al. Application of nano-and micro-particles on the topical therapy of skin-related immune disorders[J]. Current Pharmaceutical Design,2015,21(19):2643-2667.
APA Sun L.,Liu Z.,Cun D.,Tong H.H.Y.,&Zheng Y..(2015).Application of nano-and micro-particles on the topical therapy of skin-related immune disorders.Current Pharmaceutical Design,21(19),2643-2667.
MLA Sun L.,et al."Application of nano-and micro-particles on the topical therapy of skin-related immune disorders".Current Pharmaceutical Design 21.19(2015):2643-2667.
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