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Effect of sample preparation on components and liver toxicity of Polygonum multiflorum
Lv G.P.2; Meng L.Z.2; Han D.Q.2; Li H.Y.2; Zhao J.2; Li S.P.2
2015-05-01
Source PublicationJournal of Pharmaceutical and Biomedical Analysis
ISSN1873264X 07317085
Volume109Pages:105-111
AbstractIt was shown that different extracts had significant differences in the toxicity of Polygonum multiflorum. In this study, the effect of sample preparation on components and liver toxicity of different extracts from P. multiflorum were determined. Hepatoxic components were discovered based on biomembrane extraction. Comparative chemistry and toxicology between ethanol and water extracts were also performed. The results showed that ethanol extract had much stronger hepatotoxicity, the content of emodin-8-O-β-. d-glucopyranoside, physcion-8-O-β-. d-glucopyranoside, emodin and physcion was significantly higher in ethanol extract than in water extract, while the human hepatocytes extraction showed that 2,3,5,4'-tetrahydroxystilbene-2-O-β-. d-glucopyranoside, emodin-8-O-β-. d-glucopyranoside, physcion-8-O-β-. d-glucopyranoside, emodin and physcion had interaction with human hepatocytes. The hepatotoxic effect of these components was investigated on human hepatocytes LO2 cells and emodin-8-O-β-. d-glucopyranoside, physcion-8-O-β-. d-glucopyranoside, emodin and physcion were finally confirmed to be, at least partial, hepatotoxic components. The results showed that sample preparation has significant effect on components in extracts of P. multiflorum especially the components related to hepatotoxicity. Water extract, the conventional administration form of Chinese herbs, is prefer for phytotherapy before well understanding their chemistry and biological activities.
KeywordBio-specific extraction Comparative chemistry and toxiology Hepatic cytotoxicity HPLC Polygoni Multiflori
DOI10.1016/j.jpba.2015.02.029
URLView the original
Language英語
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Cited Times [WOS]:29   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Shenzhen Institute for Drug Control
2.Universidade de Macau
Recommended Citation
GB/T 7714
Lv G.P.,Meng L.Z.,Han D.Q.,et al. Effect of sample preparation on components and liver toxicity of Polygonum multiflorum[J]. Journal of Pharmaceutical and Biomedical Analysis,2015,109:105-111.
APA Lv G.P.,Meng L.Z.,Han D.Q.,Li H.Y.,Zhao J.,&Li S.P..(2015).Effect of sample preparation on components and liver toxicity of Polygonum multiflorum.Journal of Pharmaceutical and Biomedical Analysis,109,105-111.
MLA Lv G.P.,et al."Effect of sample preparation on components and liver toxicity of Polygonum multiflorum".Journal of Pharmaceutical and Biomedical Analysis 109(2015):105-111.
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