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Three new 3,4-seco-cycloartane triterpenoids from the flower of Gardenia jasminoides
Zhang, Li-Sha1; Wang, Yan-Lan1; Liu, Qian2; Zhou, Chang-Xin1; Mo, Jian-Xia1; Lin, Li-Gen3; Gan, Li-She1
2018-02
Source PublicationPHYTOCHEMISTRY LETTERS
ISSN1874-3900
Volume23Pages:172-175
Abstract

Three new 3,4-seco-cycloartane triterpenoids (1-3), including an unusual C-1 oxygenated 3,4-seco-cycloartane triterpenoid lactone (3), along with six known triterpenoids, were isolated from 95% ethanol extract of the flower of Gardenia jasminoides. Their structures were determined by spectroscopic methods, especially 2D NMR and HRESIMS techniques. Compounds 3, 4 (dikamaliartane D), and 7 (ursolic acid) showed promising cytotoxic activity against HepG2 human hepatocellular carcinoma cell line with IC50 values of 9.3, 27.7, and 39.3 mu M, respectively.

KeywordGardenia Jasminoides 3,4-seco-cycloartane Triterpenoids Cytotoxic Activity
DOI10.1016/j.phytol.2017.11.006
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal
WOS IDWOS:000426096600032
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China
2.Yinchuan Hospital of Traditional Chinese Medicine, Yinchuan, 750001, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, 999078, China
Recommended Citation
GB/T 7714
Zhang, Li-Sha,Wang, Yan-Lan,Liu, Qian,et al. Three new 3,4-seco-cycloartane triterpenoids from the flower of Gardenia jasminoides[J]. PHYTOCHEMISTRY LETTERS,2018,23:172-175.
APA Zhang, Li-Sha.,Wang, Yan-Lan.,Liu, Qian.,Zhou, Chang-Xin.,Mo, Jian-Xia.,...&Gan, Li-She.(2018).Three new 3,4-seco-cycloartane triterpenoids from the flower of Gardenia jasminoides.PHYTOCHEMISTRY LETTERS,23,172-175.
MLA Zhang, Li-Sha,et al."Three new 3,4-seco-cycloartane triterpenoids from the flower of Gardenia jasminoides".PHYTOCHEMISTRY LETTERS 23(2018):172-175.
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