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Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase
Chen X.-Q.; Zhao J.; Chen L.-X.; Wang S.-F.; Wang Y.; Li S.-P.
2018-05-01
Source PublicationPhytochemistry
ISSN00319422
Volume149Pages:103-115
AbstractEighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum. Resinacein C was isolated from a natural source for the first time. The structures of all the above compounds were elucidated by extensive spectroscopic analysis and comparisons of their spectroscopic data with those reported in the literature. Furthermore, in an in vitro assay, Resinacein C, ganoderic acid Y, lucialdehyde C, 7-oxo-ganoderic acid Z, 7-oxo-ganoderic acid Z, and lucidadiol showed strong inhibitory effects against α-glucosidase compared with the positive control drug acarbose. The structure-activity relationships of ganoderma triterpenes on α-glucosidase inhibition showed that the C-24/C-25 double bond is necessary for α-glucosidase inhibitory activity. Moreover, the carboxylic acid group at C-26 and the hydroxy group at C-15 play important roles in enhancing inhibitory effects of these triterpenes.
KeywordGanoderma resinaceum Ganodermataceae Lanostane triterpenes α-Glucosidase inhibitor
DOI10.1016/j.phytochem.2018.01.007
URLView the original
Language英語
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationUniversidade de Macau
Recommended Citation
GB/T 7714
Chen X.-Q.,Zhao J.,Chen L.-X.,et al. Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase[J]. Phytochemistry,2018,149:103-115.
APA Chen X.-Q.,Zhao J.,Chen L.-X.,Wang S.-F.,Wang Y.,&Li S.-P..(2018).Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase.Phytochemistry,149,103-115.
MLA Chen X.-Q.,et al."Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase".Phytochemistry 149(2018):103-115.
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