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C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells
Yin Z.-Q.1; Yu S.-L.1; Wei Y.-J.3; Ma L.1; Wu Z.-F.1; Wang L.5; Zhang Q.-W.6; Zhao M.4; Ye W.-C.5; Che C.-T.4; Zhang J.2
2016-02-01
Source PublicationSteroids
ISSN18785867
Volume106Pages:55-61
AbstractTwo new (1-2) and three known (3-5) C21 steroidal glycosides were isolated from Cynanchum stauntonii. Their structures were elucidated on the basis of 1D and 2D-NMR spectroscopic data as well as HRTOFMS analysis. The cytotoxicity of the compounds against A549, HepG2, and 4T1 cell lines were evaluated by MTT assay. Compound 4 exhibited good inhibitory activities with the IC50 values 26.82, 12.24, and 44.12 μM, respectively. Furthermore, compound 4 could induce G1 phase arrest, upregulate the expression levels of caspases-3, -9, and Bax, and downregulate the expression level of Bcl-2. These results indicated that compound 4 might be valuable to anticancer drug candidates.
KeywordApoptosis C(21) steroidal glycoside Caspase Cynanchum stauntonii
DOI10.1016/j.steroids.2015.12.008
URLView the original
Language英語
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.China Pharmaceutical University
2.Jiangsu Province Academy of Traditional Chinese Medicine
3.Nanjing Medical University
4.University of Illinois at Chicago
5.Jinan University
6.Universidade de Macau
Recommended Citation
GB/T 7714
Yin Z.-Q.,Yu S.-L.,Wei Y.-J.,et al. C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells[J]. Steroids,2016,106:55-61.
APA Yin Z.-Q..,Yu S.-L..,Wei Y.-J..,Ma L..,Wu Z.-F..,...&Zhang J..(2016).C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells.Steroids,106,55-61.
MLA Yin Z.-Q.,et al."C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells".Steroids 106(2016):55-61.
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