C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells

doi:10.1016/j.steroids.2015.12.008

UM > Institute of Chinese Medical Sciences

	C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells
	Yin Z.-Q.1; Yu S.-L.1; Wei Y.-J.3; Ma L.1; Wu Z.-F.1; Wang L.5; Zhang Q.-W.6 ; Zhao M.4; Ye W.-C.5; Che C.-T.4; Zhang J.2
	2016-02-01
Source Publication	Steroids
ISSN	18785867
Volume	106 Pages:55-61
Abstract	Two new (1-2) and three known (3-5) C21 steroidal glycosides were isolated from Cynanchum stauntonii. Their structures were elucidated on the basis of 1D and 2D-NMR spectroscopic data as well as HRTOFMS analysis. The cytotoxicity of the compounds against A549, HepG2, and 4T1 cell lines were evaluated by MTT assay. Compound 4 exhibited good inhibitory activities with the IC50 values 26.82, 12.24, and 44.12 μM, respectively. Furthermore, compound 4 could induce G1 phase arrest, upregulate the expression levels of caspases-3, -9, and Bax, and downregulate the expression level of Bcl-2. These results indicated that compound 4 might be valuable to anticancer drug candidates.
Keyword	Apoptosis C(21) steroidal glycoside Caspase Cynanchum stauntonii
DOI	10.1016/j.steroids.2015.12.008
URL	View the original
Language	英語
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics	Cited Times [WOS]:8 [WOS Record] [Related Records in WOS]
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Affiliation	1.China Pharmaceutical University 2.Jiangsu Province Academy of Traditional Chinese Medicine 3.Nanjing Medical University 4.University of Illinois at Chicago 5.Jinan University 6.Universidade de Macau
Recommended Citation GB/T 7714	Yin Z.-Q.,Yu S.-L.,Wei Y.-J.,et al. C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells[J]. Steroids,2016,106:55-61.
APA	Yin Z.-Q..,Yu S.-L..,Wei Y.-J..,Ma L..,Wu Z.-F..,...&Zhang J..(2016).C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells.Steroids,106,55-61.
MLA	Yin Z.-Q.,et al."C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells".Steroids 106(2016):55-61.

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