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Antitumor effects of two extracts from Oxytropis falcata on hepatocellular carcinoma in vitro and in vivo
Yang G.-M.1; Yan R.2; Wang Z.-X.3; Zhang F.-F.1; Pan Y.1; Cai B.-C.1
2013-09-01
Source PublicationChinese Journal of Natural Medicines
ISSN18755364
Volume11Issue:5Pages:519-524
Abstract

Aims: To investigate the antitumor effects of extracts from Oxytropis falcata on human hepatocellular carcinoma SMMC-7721 cells in vitro and in transplanted murine H22 tumors in vivo. Methods: Cell proliferation, cell cycle distribution and apoptosis in SMMC-7721 cells were determined and tumor growth inhibition in H22 tumors was investigated. Cell cycle distribution was analyzed by flow cytometry with propidium iodide (PI) and Annexin V-FITC/ PI double staining. Results: MTT assay revealed that essential oil and flavonoids of O. falcata (named EOOF and FOF) inhibited proliferation of SMMC-7721 cells in a dose-dependent manner. The IC value of EOOF and FOF were 0.115 and 0.097 mg·mL, respectively. Cell cycle was arrested at G phase, and induction of apoptosis occurred in SMMC-7721 cells when subjected to FOF. Growth inhibition in H22 solid tumors transplanted mice was significantly pronounced after being treated with FOF, and the inhibition ratio were 56.1% and 70.8% at the concentration of 30 and 60 mg·kg. Conclusion: The results suggest that FOF promotes apoptosis in SMMC-7721 cells and inhibits H22 tumor growth, resulting in a potential antitumor effect on hepatic cancer. © 2013 China Pharmaceutical University.

KeywordAntitumor Apoptosis Murine Hepatoma22 Oxytropis Falcata Proliferation Smmc-7721
DOI10.1016/S1875-5364(13)60094-1
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000325590000012
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Nanjing University of Traditional Chinese Medicine
2.Universidade de Macau
3.China Pharmaceutical University
Recommended Citation
GB/T 7714
Yang G.-M.,Yan R.,Wang Z.-X.,et al. Antitumor effects of two extracts from Oxytropis falcata on hepatocellular carcinoma in vitro and in vivo[J]. Chinese Journal of Natural Medicines,2013,11(5):519-524.
APA Yang G.-M.,Yan R.,Wang Z.-X.,Zhang F.-F.,Pan Y.,&Cai B.-C..(2013).Antitumor effects of two extracts from Oxytropis falcata on hepatocellular carcinoma in vitro and in vivo.Chinese Journal of Natural Medicines,11(5),519-524.
MLA Yang G.-M.,et al."Antitumor effects of two extracts from Oxytropis falcata on hepatocellular carcinoma in vitro and in vivo".Chinese Journal of Natural Medicines 11.5(2013):519-524.
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