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Fecal microbiota transplantation in experimental ulcerative colitis reveals associated gut microbial and host metabolic reprogramming
Yan Z.-X.2; Gao X.-J.2; Li T.2; Wei B.2; Wang P.-P.2; Yang Y.2; Yan R.2
2018-07-01
Source PublicationApplied and Environmental Microbiology
ISSN10985336 00992240
Volume84Issue:14
Abstract

Fecal microbiota transplantation (FMT) is gaining attention for the treatment of ulcerative colitis (UC). Data from individual case studies have suggested that FMT may be beneficial for UC, but the detailed microbial and molecular basis remains unknown. Here, we employ 16S rRNA gene sequencing and metabolomics to investigate the influence of FMT on gut microbial community composition and host metabolism in the dextran sulfate sodium-induced UC rat model. The findings from this pilot study suggest that FMT from normal donors to UC recipients could alleviate UC symptoms without close resemblance of donor's gut microbial and metabolic pattern. Meanwhile, FMT from UC donors to normal recipient rats triggered UC symptoms, UC-prone microbial shift, and host metabolic adaption. Gut microbiota under normal conditions could maintain stable species richness and diversity upon FMT intervention, but the disturbed gut microbiota under UC conditions could not maintain such homeostasis. Significant correlations between altered bacterial composition and host metabolism could be assigned to the pathological effects of UC (accounting for 8.0 to 16.2% of total variance) and/or the FMT intervention effects (3.9 to 7.0% of total variance). Overall, our study reveals diverse gut microbial shifts in UC related FMT and their association with host metabolic reprogramming.

KeywordFecal Microbiota Transplantation Gut Microbiota Host Metabolism Ulcerative Colitis
DOIhttp://doi.org/10.1128/AEM.00434-18
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Microbiology
WOS SubjectBiotechnology & Applied Microbiology ; Microbiology
WOS IDWOS:000438886400011
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Zhuhai UM Science and Technology Research Institute
2.Universidade de Macau
Recommended Citation
GB/T 7714
Yan Z.-X.,Gao X.-J.,Li T.,et al. Fecal microbiota transplantation in experimental ulcerative colitis reveals associated gut microbial and host metabolic reprogramming[J]. Applied and Environmental Microbiology,2018,84(14).
APA Yan Z.-X..,Gao X.-J..,Li T..,Wei B..,Wang P.-P..,...&Yan R..(2018).Fecal microbiota transplantation in experimental ulcerative colitis reveals associated gut microbial and host metabolic reprogramming.Applied and Environmental Microbiology,84(14).
MLA Yan Z.-X.,et al."Fecal microbiota transplantation in experimental ulcerative colitis reveals associated gut microbial and host metabolic reprogramming".Applied and Environmental Microbiology 84.14(2018).
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