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Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies
Wei B.2; Yang W.2; Yan Z.-X.2; Zhang Q.-W.2; Yan R.2
2018-09-01
Source PublicationJournal of Functional Foods
ISSN17564646
Volume48Pages:210-219
Abstract

Gut microbial β-glucuronidases show varied substrate specificity and inhibition propensity, highlighting the necessity of discovering broad-spectrum β-glucuronidase inhibitor to meet clinical needs. In this study, two prenylflavonoids sanggenon C (SGC) and kuwanon G (KWG) exhibited strong inhibition on p-nitrophenyl-β-D-glucuronide-hydrolyzing activity in pooled human gut microbiota and eight bacterial isolates, while amoxapine, a previously reported Escherichia coli β-glucuronidase (EcoGUS) inhibitor, only showed poor inhibition on the pooled samples and relatively selective inhibition on individual strains with incomplete inhibition on Staphylococcus.pasteuri 3I10. Both prenylflavonoids exhibited mixed-type inhibition against the recombinant enzymes EcoGUS and S. pasteuri 3I10 β-glucuronidase (SpasGUS). Molecular docking studies predicted phenolic groups of SGC and KWG as key structures interacting with the allosteric site of SpasGUS, while the phenolic hydroxyl (SGC) or benzopyranyl (KWG) group accounts for the hydrogen bond interaction with EcoGUS. The potentials of these broad-spectrum inhibitors in alleviating bacterial β-glucuronidase-mediated drug toxicity/efficacy warrants further investigation.

KeywordHuman Gut Microbiota Kuwanon g Molecular Docking Sanggenon c Β-glucuronidase Inhibitor
DOI10.1016/j.jff.2018.07.013
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000447573600023
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Citation statistics
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYan R.
Affiliation1.Zhuhai UM Science & Technology Research Institute
2.Universidade de Macau
Recommended Citation
GB/T 7714
Wei B.,Yang W.,Yan Z.-X.,et al. Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies[J]. Journal of Functional Foods,2018,48:210-219.
APA Wei B.,Yang W.,Yan Z.-X.,Zhang Q.-W.,&Yan R..(2018).Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies.Journal of Functional Foods,48,210-219.
MLA Wei B.,et al."Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies".Journal of Functional Foods 48(2018):210-219.
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