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Transgenic n-3 PUFAs enrichment leads to weight loss via modulating neuropeptides in hypothalamus
Ma S.2; Ge Y.2; Gai X.2; Xue M.2; Li N.2; Kang J.1; Wan J.3; Zhang J.2
2016-01-12
Source PublicationNeuroscience Letters
ISSN18727972 03043940
Volume611Pages:28-32
Abstract

Body weight is related to fat mass, which is associated with obesity. Our study explored the effect of fat-1 gene on body weight in fat-1 transgenic mice. In present study, we observed that the weight/length ratio of fat-1 transgenic mice was lower than that of wild-type mice. The serum levels of triglycerides (TG), cholesterol (CT), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) and blood glucose (BG) in fat-1 transgenic mice were all decreased. The weights of peri-bowels fat, perirenal fat and peri-testicular fat in fat-1 transgenic mice were reduced. We hypothesized that increase of n-3 PUFAs might alter the expression of hypothalamic neuropeptide genes and lead to loss of body weight in fat-1 transgenic mice. Therefore, we measured mRNA levels of appetite neuropeptides, Neuropeptide Y (NPY), Agouti-related peptides (AgRP), Proopiomelanocortin (POMC), Cocaine and amphetamine regulated transcript (CART), ghrelin and nesfatin-1 in hypothalamus by real-time PCR. Compared with wild-type mice, the mRNA levels of CART, POMC and ghrelin were higher, while the mRNA levels of NPY, AgRP and nesfatin-1 were lower in fat-1 transgenic mice. The results indicate that fat-1 gene or n-3 PUFAs participates in regulation of body weight, and the mechanism of this phenomenon involves the expression of appetite neuropeptides and lipoproteins in fat-1 transgenic mice.

KeywordBody Weight Fat-1 Gene Hypothalamus Neuropeptide
DOI10.1016/j.neulet.2015.11.029
URLView the original
Indexed BySCIE
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000368952000005
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Mathazhusazhu General Hospital
2.Qingdao University, School of Medicine
3.Universidade de Macau
Recommended Citation
GB/T 7714
Ma S.,Ge Y.,Gai X.,et al. Transgenic n-3 PUFAs enrichment leads to weight loss via modulating neuropeptides in hypothalamus[J]. Neuroscience Letters,2016,611:28-32.
APA Ma S..,Ge Y..,Gai X..,Xue M..,Li N..,...&Zhang J..(2016).Transgenic n-3 PUFAs enrichment leads to weight loss via modulating neuropeptides in hypothalamus.Neuroscience Letters,611,28-32.
MLA Ma S.,et al."Transgenic n-3 PUFAs enrichment leads to weight loss via modulating neuropeptides in hypothalamus".Neuroscience Letters 611(2016):28-32.
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