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Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting β-catenin signaling
Yin X.1; Yu X.-W.1; Zhu P.1; Zhang Y.-M.1; Zhang X.-H.1; Wang F.3; Zhang J.-J.1; Yan W.2; Xi Y.1; Wan J.-B.5; Kang J.-X.4; Zou Z.-Q.1; Bu S.-Z.1
2016-10-01
Source PublicationMolecular Medicine Reports
ISSN17913004 17912997
Volume14Issue:4Pages:3476-3484
AbstractMalignant melanoma is the most lethal form of skin cancer. Although preclinical studies have shown that n-3 polyunsaturated fatty acids (PUFAs) are beneficial for prevention of melanoma, the molecular mechanisms underlying the protective effects of n-3 PUFAs on melanoma remain largely unknown. In the present study, endogenously increased levels of n-3 PUFAs in the tumor tissues of omega-3 fatty acid desaturase (fat-1) transgenic mice was associated with a reduction in the growth rate of melanoma xenografts. This reduction in tumor growth in fat-1 mice compared with wild-type controls may have been associated, in part, to the: i) Increased expression of E-cadherin and the reduced expression of its transcriptional repressors, the zinc finger E-box binding homeobox 1 and snail family transcriptional repressor 1; ii) significant repression of the epidermal growth factor receptor/Akt/β-catenin signaling pathway; and iii) formation of significant levels of n-3 PUFA-derived lipid mediators, particularly resolvin D2 and E1, maresin 1 and 15-hydroxyeicosapentaenoic acid. In addition, vitamin E administration counteracted n-3 PUFA-induced lipid peroxidation and enhanced the antitumor effect of n-3 PUFAs, which suggests that the protective role of n-3 PUFAs against melanoma is not mediated by n-3 PUFAs-induced lipid peroxidation. These results highlight a potential role of n-3 PUFAs supplementation for the chemoprevention of melanoma in high-risk individuals, and as a putative adjuvant agent in the treatment of malignant melanoma.
KeywordE-cadherin Fat-1 Lipid mediator Melanoma β-catenin
DOI10.3892/mmr.2016.5639
URLView the original
Language英語
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Ningbo University
2.Second Hospital of Ningbo
3.Lihuili Hospital
4.Massachusetts General Hospital
5.Universidade de Macau
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Yin X.,Yu X.-W.,Zhu P.,et al. Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting β-catenin signaling[J]. Molecular Medicine Reports,2016,14(4):3476-3484.
APA Yin X..,Yu X.-W..,Zhu P..,Zhang Y.-M..,Zhang X.-H..,...&Bu S.-Z..(2016).Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting β-catenin signaling.Molecular Medicine Reports,14(4),3476-3484.
MLA Yin X.,et al."Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting β-catenin signaling".Molecular Medicine Reports 14.4(2016):3476-3484.
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