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Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition
Zhu P.1; Zhang Y.-M.1; Yin X.6; Zhang X.-H.1; Wang F.3; Zhang J.-J.1; Yan W.2; Xi Y.1; Wan J.-B.4; Kang J.-X.5; Zou Z.-Q.1; Bu S.-Z.1
2016-12-01
Source PublicationJournal of Functional Foods
ISSN17564646
Volume27Pages:483-490
AbstractMalignant melanoma is an aggressive cancer of neuroectodermal origin. The mechanisms of n-3 polyunsaturated fatty acids (PUFAs) against melanoma metastasis are not clear. Here fat-1 and wild type (WT) mice were injected with B16F10 melanoma cells via the tail vein to establish lung metastasis model. Endogenous n-3 PUFAs were associated with a reduction in grossly visible pulmonary metastases and outgrowth through inhibition of mesenchymal to epithelial transition (MET), which was characterized by decreased expression of epithelial markers E-cadherin and ZO-1, and increased expression of mesenchymal marker vimentin in tumour tissues from fat-1 mice compared with WT controls. In addition, n-3 PUFA-mediated inhibition of MET may have been associated, in part, with the: (i) formation of n-3 PUFA-derived lipid mediators and (ii) decreased expression of mature IL-1β and p-NF-κB, and enhanced expression of superoxide dismutase-1. These results suggest that n-3 PUFAs exert their antitumourigenic activities, in part, via their anti-inflammatory properties.
KeywordFat-1 IL-1β Lipid mediators Melanoma Mesenchymal to epithelial transition n-3 polyunsaturated fatty acids
DOI10.1016/j.jff.2016.10.006
URLView the original
Language英語
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Ningbo University
2.Second Hospital of Ningbo
3.Lihuili Hospital
4.Universidade de Macau
5.Massachusetts General Hospital and Harvard Medical School
6.Hangzhou First People's Hospital
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GB/T 7714
Zhu P.,Zhang Y.-M.,Yin X.,et al. Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition[J]. Journal of Functional Foods,2016,27:483-490.
APA Zhu P..,Zhang Y.-M..,Yin X..,Zhang X.-H..,Wang F..,...&Bu S.-Z..(2016).Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition.Journal of Functional Foods,27,483-490.
MLA Zhu P.,et al."Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition".Journal of Functional Foods 27(2016):483-490.
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