UM  > 健康科學學院
Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity
Han, Bing-Nan1,4; Liang, Ting-Ting2; Keen, Lawrence Jordan1; Fan, Ting-Ting1; Zhang, Xiao-Dan1; Xu, Lin1; Zhao, Qi3; Wang, Shu-Ping4; Lin, Hou-Wen4
2018-02-02
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume20Issue:3Pages:578-581
Abstract

The isolation and structure elucidation of two cyanobacterial debromoaplysiatoxin (DAT) analogues, neo-debromoaplysiatoxin A (1) and neo-debromoaplysiatoxin B (2), were reported and found to possess 6/10/6 and 6/6/6 fused-ring systems, respectively, which are rarely seen among aplysiatoxins. Both compounds exhibited potent blocking activity against Kv1.5 with IC50 values of 6.94 +/- 0.26 and 0.30 +/- 0.05 mu M, respectively. These findings suggest the potential of aplysiatoxin analogues in modulating ionic channels and also provide links between the DAT target, protein kinase C, and cell regulation.

DOI10.1021/acs.orglett.7b03672
URLView the original
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000424729800021
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorHan, Bing-Nan
Affiliation1.Zhejiang Sci Tech Univ, Coll Life Sci, Dept Dev Technol Marine Resources, Hangzhou 310018, Zhejiang, Peoples R China
2.Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China
3.Univ Macau, Fac Hlth Sci, Macau, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Dept Pharm,Ren Ji Hosp, Res Ctr Marine Drugs,State Key Lab Oncogenes & Re, Shanghai 200127, Peoples R China
Recommended Citation
GB/T 7714
Han, Bing-Nan,Liang, Ting-Ting,Keen, Lawrence Jordan,et al. Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity[J]. ORGANIC LETTERS,2018,20(3):578-581.
APA Han, Bing-Nan.,Liang, Ting-Ting.,Keen, Lawrence Jordan.,Fan, Ting-Ting.,Zhang, Xiao-Dan.,...&Lin, Hou-Wen.(2018).Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity.ORGANIC LETTERS,20(3),578-581.
MLA Han, Bing-Nan,et al."Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity".ORGANIC LETTERS 20.3(2018):578-581.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Han, Bing-Nan]'s Articles
[Liang, Ting-Ting]'s Articles
[Keen, Lawrence Jordan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Han, Bing-Nan]'s Articles
[Liang, Ting-Ting]'s Articles
[Keen, Lawrence Jordan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Han, Bing-Nan]'s Articles
[Liang, Ting-Ting]'s Articles
[Keen, Lawrence Jordan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.