UM
Nanofiber scaffolds facilitate functional regeneration of peripheral nerve injury
Zhan X.2; Gao M.1; Jiang Y.2; Zhang W.2; Wong W.M.1; Yuan Q.1; Su H.1; Kang X.2; Dai X.2; Zhang W.2; Guo J.2; Wu W.1
2013-04-01
Source PublicationNanomedicine: Nanotechnology, Biology, and Medicine
ISSN15499634 15499642
Volume9Issue:3Pages:305-315
AbstractPeripheral nerve injury still remains a refractory challenge for both clinical and basic researchers. A novel nanofiber conduit made of blood vessel and filled with amphiphilic hydrogel of self-assembling nanofiber scaffold (SAPNS) was implanted to repair a 10 mm nerve gap after sciatic nerve transection. Empty blood vessel conduit was implanted serving as control. Results showed that this novel nanofiber conduit enabled the peripheral axons to regenerate across and beyond the 10 mm gap. Motoneuron protection, axonal regeneration and remyelination were significantly enhanced with SAPNS scaffold treatments. The target reinnervation and functional recovery induced by the regenerative nerve conduit suggest that SAPNS-based conduit is highly promising application in the treatment of peripheral nerve defect. From the Clinical Editor: In this paper by Zhan et al, a novel self-assembling nanofiber scaffold is reported to promote regeneration of peripheral nerves in a sciatic nerve injury model. The promising results and the obvious medical need raises hope for a clinical translation of this approach hopefully in the near future. © 2013 Elsevier Inc.
KeywordAxonal regeneration Nanofiber scaffold Peripheral nerve injury Remyelination Self-assembling peptide
DOI10.1016/j.nano.2012.08.009
URLView the original
Language英語
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Cited Times [WOS]:49   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.The University of Hong Kong Li Ka Shing Faculty of Medicine
2.Southern Medical University
3.The University of Hong Kong
4.Hubei General Hospital
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GB/T 7714
Zhan X.,Gao M.,Jiang Y.,et al. Nanofiber scaffolds facilitate functional regeneration of peripheral nerve injury[J]. Nanomedicine: Nanotechnology, Biology, and Medicine,2013,9(3):305-315.
APA Zhan X..,Gao M..,Jiang Y..,Zhang W..,Wong W.M..,...&Wu W..(2013).Nanofiber scaffolds facilitate functional regeneration of peripheral nerve injury.Nanomedicine: Nanotechnology, Biology, and Medicine,9(3),305-315.
MLA Zhan X.,et al."Nanofiber scaffolds facilitate functional regeneration of peripheral nerve injury".Nanomedicine: Nanotechnology, Biology, and Medicine 9.3(2013):305-315.
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