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Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury
Su H.3; Yuan Q.1; Qin D.1; Yang X.1; Wong W.-M.1; So K.-F.1; Wu W.1
2013-06-27
Source PublicationBMC Surgery
ISSN14712482
Volume13Issue:1
Abstract

Background: Peripheral nerve (PN) transplantation and ventral root implantation are the two common types of recovery operations to restore the connection between motoneurons and their target muscles after brachial plexus injury. Despite experience accumulated over the past decade, fundamental knowledge is still lacking concerning the efficacy of the two microsurgical interventions. Methods. Thirty-eight adult female Sprague-Dawley rats were divided into 5 groups. Immediately following root avulsion, animals in the first group (n = 8) and the second group (n = 8) received PN graft and ventral root implantation respectively. The third group (n = 8) and the fourth group (n = 8) received PN graft and ventral root implantation respectively at one week after root avulsion. The fifth group received root avulsion only as control (n = 6). The survival and axonal regeneration of severed motoneurons were investigated at 6 weeks post-implantation. Results: Re-implantation of ventral roots, both immediately after root avulsion and in delay, significantly increased the survival and regeneration of motoneurons in the avulsed segment of the spinal cord as compared with PN graft transplantation. Conclusions: The ventral root re-implantation is a better surgical repairing procedure than PN graft transplantation for brachial plexus injury because of its easier manipulation for re-implanting avulsed ventral roots to the preferred site, less possibility of causing additional damage and better effects on motoneuron survival and axonal regeneration.

KeywordAvulsion Motoneuron Survival And Regeneration Peripheral Nerve Graft Transplantation Ventral Root Re-implantation
DOI10.1186/1471-2482-13-21
URLView the original
Indexed BySCIE
WOS Research AreaSurgery
WOS SubjectSurgery
WOS IDWOS:000321739300001
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.The University of Hong Kong Li Ka Shing Faculty of Medicine
2.Jinan University
3.Universidade de Macau
Recommended Citation
GB/T 7714
Su H.,Yuan Q.,Qin D.,et al. Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury[J]. BMC Surgery,2013,13(1).
APA Su H..,Yuan Q..,Qin D..,Yang X..,Wong W.-M..,...&Wu W..(2013).Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury.BMC Surgery,13(1).
MLA Su H.,et al."Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury".BMC Surgery 13.1(2013).
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