UM
Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3 β activation
Su H.2; Yuan Q.3; Qin D.3; Yang X.3; Wong W.-M.3; So K.-F.3; Wu W.3
2014
Source PublicationBioMed Research International
ISSN23146141 23146133
Volume2014
AbstractBrachial plexus injury often involves traumatic root avulsion resulting in permanent paralysis of the innervated muscles. The lack of sufficient regeneration from spinal motoneurons to the peripheral nerve (PN) is considered to be one of the major causes of the unsatisfactory outcome of various surgical interventions for repair of the devastating injury. The present study was undertaken to investigate potential inhibitory signals which influence axonal regeneration after root avulsion injury. The results of the study showed that root avulsion triggered GSK-3β activation in the injured motoneurons and remaining axons in the ventral funiculus. Systemic application of a clinical dose of lithium suppressed activated GSK-3β in the lesioned spinal cord to the normal level and induced extensive axonal regeneration into replanted ventral roots. Our study suggests that GSK-3β activity is involved in negative regulation for axonal elongation and regeneration and lithium, the specific GSK-3β inhibitor, enhances motoneuron regeneration from CNS to PNS. © 2014 Huanxing Su et al.
DOI10.1155/2014/658753
URLView the original
Language英語
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Jinan University
2.Universidade de Macau
3.The University of Hong Kong Li Ka Shing Faculty of Medicine
Recommended Citation
GB/T 7714
Su H.,Yuan Q.,Qin D.,et al. Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3 β activation[J]. BioMed Research International,2014,2014.
APA Su H..,Yuan Q..,Qin D..,Yang X..,Wong W.-M..,...&Wu W..(2014).Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3 β activation.BioMed Research International,2014.
MLA Su H.,et al."Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3 β activation".BioMed Research International 2014(2014).
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