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Increased endothelial progenitor cells and nitric oxide in young prehypertensive women
Zhen Y.1; Xiao S.1; Ren Z.3; Shen H.-W.1; Su H.4; Tang Y.-B.2; Zeng H.1
2015
Source PublicationJournal of Clinical Hypertension
ISSN17517176 15246175
Volume17Issue:4Pages:298-305
AbstractThis study investigated the effect of sex differences on circulating endothelial progenitor cells (EPCs) in prehypertension and its underlying mechanism. The authors found that premenopausal women show increased number and activity of circulating EPCs when compared with men, which was similar to enhanced nitric oxide (NO) level in plasma or culture medium. There was no difference in the number and activity of circulating EPCs and NO level between normotensive and prehypertensive premenopausal women. There was also no difference seen in levels of vascular endothelial growth factor and granulocyte macrophage colony-stimulating factor. Both number and activity of circulating EPCs were correlated with the level of NO. The present study firstly demonstrated that the number and activity of circulating EPCs were preserved in prehypertensive premenopausal women, which was related to the restoration of NO production. The sex differences in EPCs in prehypertension may be involved in the mechanism underlying vascular protection in premenopausal women.
DOI10.1111/jch.12493
URLView the original
Language英語
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被引频次[WOS]:11   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题University of Macau
Affiliation1.Sun Yat-Sen University
2.Sun Yat-Sen University, Zhongshan School of Medicine
3.Guangdong General Hospital
4.Universidade de Macau
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GB/T 7714
Zhen Y.,Xiao S.,Ren Z.,et al. Increased endothelial progenitor cells and nitric oxide in young prehypertensive women[J]. Journal of Clinical Hypertension,2015,17(4):298-305.
APA Zhen Y..,Xiao S..,Ren Z..,Shen H.-W..,Su H..,...&Zeng H..(2015).Increased endothelial progenitor cells and nitric oxide in young prehypertensive women.Journal of Clinical Hypertension,17(4),298-305.
MLA Zhen Y.,et al."Increased endothelial progenitor cells and nitric oxide in young prehypertensive women".Journal of Clinical Hypertension 17.4(2015):298-305.
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