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Synthesis and antitumor activity of novel salvicine analogues
Deng F.1; Lu J.J.1; Liu H.Y.2; Lin L.P.1; Ding J.1; Zhang J.S.1
2011
Source PublicationChinese Chemical Letters
ISSN10018417
Volume22Issue:1Pages:25-28
Abstract

Systematic structure modification of the side train of the lead compound saprothoquinone provides a series of salvicine analogues, fifteen of them were first reported. Some compounds were demonstrated potent cytotoxicity against tumor cells with the 50% inhibition concentration in the micromolar range. Furthermore some compounds showed potent topoisomerase II inhibitory effects. The preliminary structure-activity relationship of saprorthoquinone analogues was discussed according to their cytotoxicity against three tumor cells. © 2010 Fei Deng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

KeywordAntitumor Salvicine Saprorthoquinone Structural Modification
DOI10.1016/j.cclet.2010.07.009
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000286551700007
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences
2.Northwest A&F University
Recommended Citation
GB/T 7714
Deng F.,Lu J.J.,Liu H.Y.,et al. Synthesis and antitumor activity of novel salvicine analogues[J]. Chinese Chemical Letters,2011,22(1):25-28.
APA Deng F.,Lu J.J.,Liu H.Y.,Lin L.P.,Ding J.,&Zhang J.S..(2011).Synthesis and antitumor activity of novel salvicine analogues.Chinese Chemical Letters,22(1),25-28.
MLA Deng F.,et al."Synthesis and antitumor activity of novel salvicine analogues".Chinese Chemical Letters 22.1(2011):25-28.
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