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Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells
Lu J.-J.2; Cai Y.-J.2; Ding J.2
2011-08-01
Source PublicationMolecular and Cellular Biochemistry
ISSN03008177 15734919
Volume354Issue:1-2Pages:247-252
Abstract

Curcumin (CUR), a polyphenol derived from the plant Curcuma longa, displays potential anti-cancer activity. One of the mechanisms stems from its ability to elicit cell cycle arrest followed by suppression of cell proliferation. Herein, we reported that CUR significantly induced DNA damage and mediated S and G2/M phase arrest in colorectal carcinoma HCT116 cells. Unlike etoposide, a classical topoisomerase II inhibitor, CUR-triggered G2/M phase arrest was hardly reversed by caffeine (CAFF) which is an inhibitor of activated ataxia-telangiectasia- mutated (ATM)/ATM- and Rad3-related (ATR), indicating that ATM and ATR signaling pathways may be not involved in CUR-mediated S and G2/M phase arrest in HCT116 cells. Furthermore, we demonstrated that CUR caused mitosis arrest in HCT116 cells by using mitotic protein monoclonal antibody-2 as a mitosis marker and the surface plasmon resonance assay. The findings provide new mechanisms of cell proliferation inhibition triggered by CUR in HCT116 cells. © 2011 Springer Science+Business Media, LLC.

KeywordCaffeine Curcumin Dna Damage Mitosis Arrest s Phase Arrest Tubulin
DOI10.1007/s11010-011-0824-3
URLView the original
Indexed BySCI
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000292215600026
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Cited Times [WOS]:35   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Zhejiang Chinese Medical University
2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Lu J.-J.,Cai Y.-J.,Ding J.. Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells[J]. Molecular and Cellular Biochemistry,2011,354(1-2):247-252.
APA Lu J.-J.,Cai Y.-J.,&Ding J..(2011).Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells.Molecular and Cellular Biochemistry,354(1-2),247-252.
MLA Lu J.-J.,et al."Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells".Molecular and Cellular Biochemistry 354.1-2(2011):247-252.
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