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The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells
Lu J.-J.1; Cai Y.-J.2; Ding J.2
2012
Source PublicationMolecular and Cellular Biochemistry
ISSN03008177 15734919
Volume360Issue:1-2Pages:253-260
Abstract

The anti-cancer activities of curcumin (CUR), a polyphenol derived from the plant Curcuma longa, has been extensively studied. In the present study, we found that CUR displayed anti-multidrug-resistant (MDR) activity in K562/A02 cells. A short-time treatment with CUR sufficiently and equally induced DNA damage, decreased cell viability, and triggered apoptosis in parent K562 and MDR K562/A02 cells. The short-time treatment with CUR also caused decrease of pro-caspase 3 in both cell lines and decrease of pro-caspase 9, increase of PARP cleavage and the ratio of Bax/Bcl-xL in MDR K562/A02 cells. Further experiment revealed that CUR was capable of down-regulating P-glycoprotein in MDR K562/A02 cells. Moreover, we observed that Cu enhanced CUR-mediated apoptosis which was blocked by antioxidants N-acetyl-cysteine and catalase. In summary, the short-time treatment with CUR sufficiently induced DNA damage, decreased cell viability and triggered apoptosis in MDR K562/A02 cells and Cu enhanced CUR-mediated apoptosis which due to reactive oxygen species generation. © 2011 Springer Science+Business Media, LLC.

KeywordApoptosis Copper Curcumin Dna Damage Multidrug-resistant
DOI10.1007/s11010-011-1064-2
URLView the original
Indexed BySCI
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000297722800027
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Cited Times [WOS]:25   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Zhejiang Chinese Medical University
2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Lu J.-J.,Cai Y.-J.,Ding J.. The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells[J]. Molecular and Cellular Biochemistry,2012,360(1-2):253-260.
APA Lu J.-J.,Cai Y.-J.,&Ding J..(2012).The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells.Molecular and Cellular Biochemistry,360(1-2),253-260.
MLA Lu J.-J.,et al."The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells".Molecular and Cellular Biochemistry 360.1-2(2012):253-260.
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