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Dihydroartemisinin-induced inhibition of proliferation in BEL-7402 cells: An analysis of the mitochondrial proteome
Lu J.-J.2; Yang Z.2; Lu D.-Z.2; Wo X.-D.2; Shi J.-J.2; Lin T.-Q.2; Wang M.-M.2; Li Y.2; Tang L.-H.2
2012-08-01
Source PublicationMolecular Medicine Reports
ISSN17912997 17913004
Volume6Issue:2Pages:429-433
Abstract

Artemisinin, the active ingredient of the Chinese medicinal herb Artemisia annua L., and its derivatives (ARTs) are currently widely used as anti-malarial drugs around the world. In this study, we found that dihydroartemisinin (DHA), one of the main active metabolites of ARTs, inhibited the proliferation of human hepatocarcinoma BEL-7402 cells in a concentration-dependent manner. To interpret the mechanisms involved, an analysis of the mitochondrial proteome was performed employing two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Seven mitochondrial proteins including fumarate hydratase, 60 kDa heat shock protein, enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, two subunits of ATP synthase and NADPH:adrenodoxin oxidoreductase were identified to be differentially expressed between the control and DHA-treated groups. Our results indicate that the imbalance of energy metabolism induced by DHA may contribute, at least in part, to its anti-cancer potential in BEL-7402 cells.

KeywordDihydroartemisinin Energy Metabolism Hepatocarcinoma Mitochondria Proteomics
DOI10.3892/mmr.2012.906
URLView the original
Indexed BySCI
WOS Research AreaOncology ; Research & Experimental Medicine
WOS SubjectOncology ; Medicine, Research & Experimental
WOS IDWOS:000305927700031
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Universidade de Macau
2.Zhejiang Chinese Medical University
Recommended Citation
GB/T 7714
Lu J.-J.,Yang Z.,Lu D.-Z.,et al. Dihydroartemisinin-induced inhibition of proliferation in BEL-7402 cells: An analysis of the mitochondrial proteome[J]. Molecular Medicine Reports,2012,6(2):429-433.
APA Lu J.-J..,Yang Z..,Lu D.-Z..,Wo X.-D..,Shi J.-J..,...&Tang L.-H..(2012).Dihydroartemisinin-induced inhibition of proliferation in BEL-7402 cells: An analysis of the mitochondrial proteome.Molecular Medicine Reports,6(2),429-433.
MLA Lu J.-J.,et al."Dihydroartemisinin-induced inhibition of proliferation in BEL-7402 cells: An analysis of the mitochondrial proteome".Molecular Medicine Reports 6.2(2012):429-433.
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