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Biological activities of salvianolic acid B from Salvia miltiorrhiza on type 2 diabetes induced by high-fat diet and streptozotocin
Huang M.2; Wang P.1; Xu S.2; Xu W.2; Xu W.2; Chu K.2; Lu J.3
2015-07-01
Source PublicationPharmaceutical Biology
ISSN17445116 13880209
Volume53Issue:7Pages:1058-1065
Abstract

Salvia miltiorrhiza Bge. (Labiatae) has been widely used for treating diabetes for centuries. Salvianolic acid B (SalB) is the main bioactive component in Salvia miltiorrhiza; however, its antidiabetic activity and possible mechanism are not yet clear. Objective: To investigate the effects of SalB on glycometabolism, lipid metabolism, insulin resistance, oxidative stress, and glycogen synthesis in type 2 diabetic rat model. Materials and methods: High-fat diet (HFD) and streptozotocin-induced diabetic rats were randomly divided into model group, SalB subgroups (50, 100, and 200mg/kg), and rosiglitazone group. Results: Compared with the model group, SalB (100 and 200mg/kg) significantly decreased blood glucose (by 23.8 and 21.7%; p<0.05 and p<0.01) and insulin (by 31.3 and 26.6%; p<0.05), and increased insulin sensitivity index (by 10.9 and 9.3%; p<0.05). They also significantly decreased total cholesterol (by 24.9 and 27.9%; p<0.01), low-density lipoprotein cholesterol (by 56.2 and 64.6%; p<0.01), non-esterified fatty acids (by 32.1 and 37.9%; p<0.01), hepatic glycogen (by 41.3 and 60.5%; p<0.01), and muscle glycogen (by 33.2 and 38.6%; p<0.05), and increased high-density lipoprotein cholesterol (by 50.0 and 61.4%; p<0.05 and p<0.01), which were originally altered by HFD and streptozotocin. In addition, SalB (200mg/kg) markedly decreased triglyceride and malondialdehyde (by 31.5 and 29.0%; p<0.05 and p<0.01), and increased superoxide dismutase (by 56.6%; p<0.01), which were originally altered by HFD and streptozotocin. Discussion and conclusion: The results indicate that SalB can inhibit symptoms of diabetes mellitus in rats and these effects may partially be correlated with its insulin sensitivity, glycogen synthesis and antioxidant activities.

KeywordDiabetes Glycogen Synthesis Insulin Resistance Oxidative Stress
DOI10.3109/13880209.2014.959611
URLView the original
Indexed BySCI
WOS Research AreaPlant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
WOS IDWOS:000361336300015
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Cited Times [WOS]:26   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.First Affiliated Hospital Chengdu
2.Fujian University of Traditional Chinese Medicine
3.Universidade de Macau
Recommended Citation
GB/T 7714
Huang M.,Wang P.,Xu S.,et al. Biological activities of salvianolic acid B from Salvia miltiorrhiza on type 2 diabetes induced by high-fat diet and streptozotocin[J]. Pharmaceutical Biology,2015,53(7):1058-1065.
APA Huang M..,Wang P..,Xu S..,Xu W..,Xu W..,...&Lu J..(2015).Biological activities of salvianolic acid B from Salvia miltiorrhiza on type 2 diabetes induced by high-fat diet and streptozotocin.Pharmaceutical Biology,53(7),1058-1065.
MLA Huang M.,et al."Biological activities of salvianolic acid B from Salvia miltiorrhiza on type 2 diabetes induced by high-fat diet and streptozotocin".Pharmaceutical Biology 53.7(2015):1058-1065.
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