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PH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy
Xing L.1; Lyu J.-Y.1; Yang Y.1; Cui P.-F.1; Gu L.-Q.1; Qiao J.-B.1; He Y.-J.1; Zhang T.-Q.1; Sun M.1; Lu J.-J.2; Xu X.1; Liu Y.1; Jiang H.-L.1
2017
Source PublicationChemical Communications
ISSN1364548X 13597345
Volume53Issue:62Pages:8790-8793
Abstract

We have developed mitochondria-targeted self-assembled nanoparticles (NPs) based on amphiphilic triphenylphosphine-quercetin (TPP-Que) conjugates, which were further modified by poly(ethylene glycol) via a pH-responsive coordination bond to form TQ-PEG NPs. And it is revealed that the TQ-PEG NPs were more effective therapeutic agents compared with Que in vitro and in vivo.

DOI10.1039/c7cc04058j
URLView the original
Indexed BySCI
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000406669000039
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.China Pharmaceutical University
2.Universidade de Macau
Recommended Citation
GB/T 7714
Xing L.,Lyu J.-Y.,Yang Y.,et al. PH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy[J]. Chemical Communications,2017,53(62):8790-8793.
APA Xing L..,Lyu J.-Y..,Yang Y..,Cui P.-F..,Gu L.-Q..,...&Jiang H.-L..(2017).PH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy.Chemical Communications,53(62),8790-8793.
MLA Xing L.,et al."PH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy".Chemical Communications 53.62(2017):8790-8793.
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