UM  > 中華醫藥研究院
Synthesis and evaluation of novel: O 2-derived diazeniumdiolates as photochemical and real-time monitoring nitric oxide delivery agents
Luo X.1; Wu J.1; Lv T.1; Lai Y.1; Zhang H.1; Lu J.-J.2; Zhang Y.1; Huang Z.1
2017-12-01
Source PublicationOrganic Chemistry Frontiers
ISSN20524129 20524110
Volume4Issue:12Pages:2445-2449
Abstract

A group of photochemical nitric oxide (NO) delivery agents, O-(4-hydroxyphenacyl) diazeniumdiolates 1-2 as well as O-(3-(benzothiazole-2-yl)-4-hydroxyphenacyl) diazeniumdiolates 3-4, could be triggered by ultraviolet light (365-400 nm) and visible light (≥410 nm), respectively, to produce NO in cancer cells and generate potent antitumor activity. Importantly, with the photolysis of 3 being initiated, the accompanying distinct fluorescence color change (from green to blue) may act as a qualitative real-time optical indicator for NO release in cancer cells.

DOI10.1039/c7qo00695k
URLView the original
Indexed BySCI
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000416065700026
Fulltext Access
Citation statistics
Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.China Pharmaceutical University
2.Universidade de Macau
Recommended Citation
GB/T 7714
Luo X.,Wu J.,Lv T.,et al. Synthesis and evaluation of novel: O 2-derived diazeniumdiolates as photochemical and real-time monitoring nitric oxide delivery agents[J]. Organic Chemistry Frontiers,2017,4(12):2445-2449.
APA Luo X..,Wu J..,Lv T..,Lai Y..,Zhang H..,...&Huang Z..(2017).Synthesis and evaluation of novel: O 2-derived diazeniumdiolates as photochemical and real-time monitoring nitric oxide delivery agents.Organic Chemistry Frontiers,4(12),2445-2449.
MLA Luo X.,et al."Synthesis and evaluation of novel: O 2-derived diazeniumdiolates as photochemical and real-time monitoring nitric oxide delivery agents".Organic Chemistry Frontiers 4.12(2017):2445-2449.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Luo X.]'s Articles
[Wu J.]'s Articles
[Lv T.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Luo X.]'s Articles
[Wu J.]'s Articles
[Lv T.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Luo X.]'s Articles
[Wu J.]'s Articles
[Lv T.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.