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Synthesis and Evaluation of O 2-Derived Diazeniumdiolates Activatable via Bioorthogonal Chemistry Reactions in Living Cells
Lv T.2; Wu J.2; Kang F.2; Wang T.2; Wan B.2; Lu J.-J.1; Zhang Y.2; Huang Z.2
2018-04-20
Source PublicationOrganic Letters
ISSN15237052 15237060
Volume20Issue:8Pages:2164-2167
Abstract

A class of O-alkyl derived diazeniumdiolates 3a-f and 4a-c were designed and synthesized as new bioorthogonal NO precursors, which can be effectively uncaged in the presence of a palladium catalyst via bioorthogonal bond cleavage reactions to generate NO in living cancer cells, eliciting potent antiproliferative activity.

DOI10.1021/acs.orglett.8b00423
URLView the original
Indexed BySCI
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000430898200009
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Universidade de Macau
2.China Pharmaceutical University
Recommended Citation
GB/T 7714
Lv T.,Wu J.,Kang F.,et al. Synthesis and Evaluation of O 2-Derived Diazeniumdiolates Activatable via Bioorthogonal Chemistry Reactions in Living Cells[J]. Organic Letters,2018,20(8):2164-2167.
APA Lv T..,Wu J..,Kang F..,Wang T..,Wan B..,...&Huang Z..(2018).Synthesis and Evaluation of O 2-Derived Diazeniumdiolates Activatable via Bioorthogonal Chemistry Reactions in Living Cells.Organic Letters,20(8),2164-2167.
MLA Lv T.,et al."Synthesis and Evaluation of O 2-Derived Diazeniumdiolates Activatable via Bioorthogonal Chemistry Reactions in Living Cells".Organic Letters 20.8(2018):2164-2167.
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