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Discrimination of multi-origin chinese herbal medicines using gas chromatography-mass spectrometry-based fatty acid profiling
Zhang X.-J.2; Qiu J.-F.2; Guo L.-P.1; Wang Y.3; Li P.2; Yang F.-Q.3; Su H.2; Wan J.-B.2
2013-12-01
Source PublicationMolecules
ISSN14203049
Volume18Issue:12Pages:15329-15343
Abstract

Multi-origin Chinese herbal medicines, with herbs originating from more than one species of plants, is a common phenomenon but an important issue in Traditional Chinese Medicines (TCMs). In the present study, a gas chromatography-mass spectrometry (GC-MS)-based fatty acid profiling approach to rapidly discriminate multi-origin Chinese medicines in terms of species and medicinal parts was proposed and validated using tuberous roots (Curcumae Radix) and rhizomes (Curcumae Rhizoma and Curcumae Longae Rhizoma) derived from four Curcuma species (e.g., C. wenyujin, C. kwangsiensis, C. phaeocaulis and C. longa) as models. Both type and content of fatty acids varied among different species of either tuberous roots or rhizomes, indicating each species has its own fatty acid pattern. Orthogonal partial least squares discriminant analysis (OPLS-DA) and hierarchical clustering analysis (HCA) based on dataset of global fatty acid profiling showed that either tuberous roots or rhizomes samples could be clearly classified into four clusters according to their species. Furthermore, those tested samples could also be discriminated in terms of their medicinal parts (e.g., tuberous root and rhizome). Our findings suggest that the proposed GC-MS-based fatty acid profiling followed by multivariate statistical analysis provides a reliable platform to discriminate multi-origin Chinese herbal medicines according to species and medicinal parts, which will be helpful for ensuring their quality, safety and efficacy. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

KeywordCurcuma Species Fatty Acid Profiling Gas Chromatography-mass Spectrometry Multi-origin Chinese Herbal Medicine Multivariate Statistical Analysis
DOI10.3390/molecules181215329
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000330315700056
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被引频次[WOS]:11   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Corresponding AuthorSu H.; Wan J.-B.
Affiliation1.China Academy of Chinese Medical Sciences
2.Universidade de Macau
3.Chongqing University
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Zhang X.-J.,Qiu J.-F.,Guo L.-P.,et al. Discrimination of multi-origin chinese herbal medicines using gas chromatography-mass spectrometry-based fatty acid profiling[J]. Molecules,2013,18(12):15329-15343.
APA Zhang X.-J..,Qiu J.-F..,Guo L.-P..,Wang Y..,Li P..,...&Wan J.-B..(2013).Discrimination of multi-origin chinese herbal medicines using gas chromatography-mass spectrometry-based fatty acid profiling.Molecules,18(12),15329-15343.
MLA Zhang X.-J.,et al."Discrimination of multi-origin chinese herbal medicines using gas chromatography-mass spectrometry-based fatty acid profiling".Molecules 18.12(2013):15329-15343.
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