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Cytotoxicity of pregnane glycosides of Cynanchum otophyllum
Zhang M.2; Li X.2; Xiang C.2; Qin Y.2; He J.2; Li B.-C.2; Li P.1
2015-12-01
Source PublicationSteroids
ISSN18785867 0039128X
Volume104Pages:49-60
AbstractFourteen new pregnane glycosides, including nine caudatin glycosides (1-9), three qinyangshengenin glycosides (10-12), one kidjoranin glycosides (13) and one gagaminin glycosides (14), along with twelve known analogs (15-26) were isolated from roots of Cynanchum otophyllum Schneid. Their structures were deduced by detailed analysis of 1D and 2D NMR spectra, as well as HRESIMS. In this study, all pregnane glycosides obtained (1-26) were evaluated for their cytotoxic activities using three cancer cell lines (HepG2, Hela, U251). As results, except 6 and 10, other twenty-four pregnane glycosides showed cytotoxicities at different degrees against three cell lines.
KeywordCynanchum otophyllum Cytotoxicity Pregnane glycosides
DOI10.1016/j.steroids.2015.08.010
URLView the original
Language英語
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Universidade de Macau
2.Kunming University of Science and Technology
Recommended Citation
GB/T 7714
Zhang M.,Li X.,Xiang C.,et al. Cytotoxicity of pregnane glycosides of Cynanchum otophyllum[J]. Steroids,2015,104:49-60.
APA Zhang M..,Li X..,Xiang C..,Qin Y..,He J..,...&Li P..(2015).Cytotoxicity of pregnane glycosides of Cynanchum otophyllum.Steroids,104,49-60.
MLA Zhang M.,et al."Cytotoxicity of pregnane glycosides of Cynanchum otophyllum".Steroids 104(2015):49-60.
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