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C21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells
Qian X.2; Li B.2; Li P.1; Wang D.2; Dai W.2; Zhang M.2
2017-08-01
Source PublicationPhytochemistry
ISSN00319422
Volume140Pages:1-15
AbstractTwenty-three undescribed previously C steroidal glycosides, named saccatols D–K and cynsaccatols I−W, together with six known analogs were isolated from the roots of Cynanchum auriculatum Royle ex Wight (Apocynaceae). Their structures were elucidated by a variety of spectroscopic techniques, as well as HRESIMS and GC method. All isolated compounds were tested their neuroprotective effects on the model of HO-induced damage to PC12 cells. Except saccatols D–F, J, cynsaccatol V and wilfoside A, other twenty-three isolates produced significantly activities against HO-induced cell damage (P < 0.001). Furthermore, cynsaccatols I, N, O and S can obvious inhibition of damaged PC12 cell apoptosis at their dosages of 1 μM by Annexin V-FITC/PI double staining assay with flow cytometry.
KeywordApocynaceae Apoptosis C21 steroidal glycosides Cynanchum auriculatum Neuroprotecton PC12
DOI10.1016/j.phytochem.2017.04.014
URLView the original
Language英語
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Universidade de Macau
2.Kunming University of Science and Technology
Recommended Citation
GB/T 7714
Qian X.,Li B.,Li P.,et al. C21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells[J]. Phytochemistry,2017,140:1-15.
APA Qian X.,Li B.,Li P.,Wang D.,Dai W.,&Zhang M..(2017).C21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells.Phytochemistry,140,1-15.
MLA Qian X.,et al."C21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells".Phytochemistry 140(2017):1-15.
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