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The bone-protecting efficiency of Chinese medicines compared with Western medicines in rheumatoid arthritis: A systematic review and meta-analysis of comparative studies
Cai X.1; Chen X.-M.1; Xia X.1; Bao K.1; Wang R.-R.1; Peng J.-H.2; Liu H.-J.3; Yang Q.-W.1; Yan J.-Y.1; Wang M.-J.1; Yu H.7; Lu J.-J.7; Hu Y.-J.7; Jakobsson P.-J.4; Wen Z.-H.5; Huang R.-Y.1; Huang Q.-C.1
2018-08-30
Source PublicationFrontiers in Pharmacology
ISSN16639812
Volume9Issue:AUG
Abstract

Background: Rheumatoid Arthritis (RA) is a systemic autoimmune disease leading to joint destruction. The prevention of bone and cartilage destruction has received increased attention in recent years. Objective: To evaluate the current evidences regarding the bone-protecting efficacy of Chinese medicine or the combination of Chinese medicine and Western medicine for RA. Methods: We comprehensively searched PubMed, Embase, the Cochrane Library (www.thecochranelibrary.com), the China National Knowledge Infrastructure (CNKI), the Database for Chinese Technical Periodicals (VIP), and SinoMed. We then performed a systematic review and cumulative meta-analysis of all randomized controlled trials (RCTs) assessing the two therapy methods. Results: Sixteen studies including 1,171 patients were included in the final analysis. The results showed that Chinese medicine could significantly improve the bone mineral density (BMD) (mean difference [MD] = 0.05 /g·cm, 95% CI [0.03, 0.08], P < 0.00001), and decrease the serum matrix metalloproteinase 3 (MMP-3) ([SMD] = -2.84, 95% CI [-4.22, -1.47], P < 0.0001). Conclusions: Chinese medicine may provide an efficiently alternative choice for the treatment of RA in terms of the bone-protecting efficiency. Given the inherent limitations of the included studies, future well-designed RCTs are required to confirm and update the findings of this analysis.

KeywordBone-protecting Efficiency Chinese Medicine Meta-analysis Rheumatoid Arthritis (Ra) Systematic Review
DOI10.3389/fphar.2018.00914
URLView the original
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000443127800001
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Guangzhou University of Traditional Chinese Medicine
2.Dongguan Hospital of Traditional Chinese Medicine
3.Central Hospital of Panyu District
4.Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome
5.Karolinska University Hospital
6.Utrecht University
7.Universidade de Macau
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GB/T 7714
Cai X.,Chen X.-M.,Xia X.,et al. The bone-protecting efficiency of Chinese medicines compared with Western medicines in rheumatoid arthritis: A systematic review and meta-analysis of comparative studies[J]. Frontiers in Pharmacology,2018,9(AUG).
APA Cai X..,Chen X.-M..,Xia X..,Bao K..,Wang R.-R..,...&Huang Q.-C..(2018).The bone-protecting efficiency of Chinese medicines compared with Western medicines in rheumatoid arthritis: A systematic review and meta-analysis of comparative studies.Frontiers in Pharmacology,9(AUG).
MLA Cai X.,et al."The bone-protecting efficiency of Chinese medicines compared with Western medicines in rheumatoid arthritis: A systematic review and meta-analysis of comparative studies".Frontiers in Pharmacology 9.AUG(2018).
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