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Comparative assessment of in vitro thrombolytic and fibrinolysis activity of four aloe species and analysis of their phenolic compounds by LC–MS
Fan J.J.3; Li C.H.1; Hu Y.J.2; Chen H.3; Yang F.Q.3
2018-11-01
Source PublicationSouth African Journal of Botany
ISSN02546299
Volume119Pages:325-334
AbstractAloe barbadensis, A. vera var. chinensis, A. ferox and A. arborescens are the most widely cultivated and used aloe species due to their potential and potent bioactivity. In this study, clot lysis and fibrin plate model were used to assess the in vitro thrombolytic and fibrinolysis activity of protein and phenolic extracts, as well as three pure compounds (aloin A, Aloin B and aloe emodin) from aloe. Meanwhile, the phenolic compounds in aloe were analyzed by high-performance liquid chromatography (HPLC) and LC–mass spectrometry (LC–MS). The in vitro thrombolytic and fibrinolytic activity assay results indicated that the protein and phenolic extracts of four aloe species had good clot lysis, fibrinolytic activity and enzyme activity, and aloin A and aloin B may be the main active ingredients. In addition, the chromatographic analysis shows obviously differences in components, such as aloenin A, isoaloeresin D and aloesin.
KeywordAloe vera Fibrinolysis LC–MS analysis Phenolic compound Protein Thrombolytic
DOI10.1016/j.sajb.2018.10.001
URLView the original
Language英語
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Sunshine Lake Pharma Co., Ltd
2.Universidade de Macau
3.Chongqing University
Recommended Citation
GB/T 7714
Fan J.J.,Li C.H.,Hu Y.J.,et al. Comparative assessment of in vitro thrombolytic and fibrinolysis activity of four aloe species and analysis of their phenolic compounds by LC–MS[J]. South African Journal of Botany,2018,119:325-334.
APA Fan J.J.,Li C.H.,Hu Y.J.,Chen H.,&Yang F.Q..(2018).Comparative assessment of in vitro thrombolytic and fibrinolysis activity of four aloe species and analysis of their phenolic compounds by LC–MS.South African Journal of Botany,119,325-334.
MLA Fan J.J.,et al."Comparative assessment of in vitro thrombolytic and fibrinolysis activity of four aloe species and analysis of their phenolic compounds by LC–MS".South African Journal of Botany 119(2018):325-334.
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