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MiRNA-Target network analysis identifies potential biomarkers for Traditional Chinese Medicine (TCM) syndrome development evaluation in hepatitis B caused liver cirrhosis
Liu Y.1; Wang M.3; Luo Y.1; Chen C.1; Lu Y.1; Shi Y.1; Tang C.1; Zhou Q.1; Zhang H.1; Hu Y.2; Su S.1; Chen Q.1
2017-12-01
Source PublicationScientific Reports
ISSN20452322
Volume7Issue:1
AbstractHepatitis B is one of most etiologies of Liver cirrhosis in China, and clinically lacks the effective strategy for Hepatitis B caused cirrhosis (HBC) therapy. As a complementary and alternative medicine, Chinese Traditional Medicine (TCM) has special therapeutic effects for HBC. Here, we focus on the evolution process of HBC TCM syndromes, which was from Excessive (Liver-Gallbladder Dampness-Heat Syndrome, LGDHS) to Deficient (Liver-Kidney Deficiency Syndrome, LKYDS) via Excessive-Deficient syndrome (Liver-Depression and Spleen-Deficiency Syndrome, LDSDS). Using R package, 16 miRNAs in LGDHS/Normal, 48 miRNAs in LDSDS/LGDHS, and 16 miRNAs in LKYDS/LDSDS were identified, respectively. The miRNA-Target networks show that the LDSDS was most stability and complicated. Subsequently, 4 kernel miRNAs with LGDHS-LDSDS process, and 5 kernel miRNAs with LDSDS-LKYDS process were screened. Using RT-qPCR data, p1 (hsa-miR-17-3p,-377-3p,-410-3p and-495) and p2 miRNA panel (hsa-miR-377-3p,-410-3p,-27a-3p, 149-5p and 940) were identified by Logistic Regression Model, which clearly improve the accuracy of TCM syndrome classification. The rebuilt miRNA-Target network shows that the LDSDS is a critical point and might determine the evolution directions of HBC TCM syndrome. This study suggests that the identified kernel miRNAs act as potential biomarkers and benefit to evaluate the evolution tendency of HBC TCM syndromes.
DOI10.1038/s41598-017-11351-5
URLView the original
Language英語
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shanghai University of Traditional Chinese Medicine
2.Universidade de Macau
3.Shanghai University of Medicine & Health Sciences
Recommended Citation
GB/T 7714
Liu Y.,Wang M.,Luo Y.,et al. MiRNA-Target network analysis identifies potential biomarkers for Traditional Chinese Medicine (TCM) syndrome development evaluation in hepatitis B caused liver cirrhosis[J]. Scientific Reports,2017,7(1).
APA Liu Y..,Wang M..,Luo Y..,Chen C..,Lu Y..,...&Chen Q..(2017).MiRNA-Target network analysis identifies potential biomarkers for Traditional Chinese Medicine (TCM) syndrome development evaluation in hepatitis B caused liver cirrhosis.Scientific Reports,7(1).
MLA Liu Y.,et al."MiRNA-Target network analysis identifies potential biomarkers for Traditional Chinese Medicine (TCM) syndrome development evaluation in hepatitis B caused liver cirrhosis".Scientific Reports 7.1(2017).
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