UM
Effect of active compounds isolated from Pteris semipinnata L on DNA topoisomerases and tyrosine protein kinase and expression of c-myc in lung adenocarcinoma cells
Li J.-H.; Liang N.-C.; Mo L.-E.; Zhang X.; He C.-W.
2001
Source PublicationChinese Journal of Cancer Research
ISSN10009604
Volume13Issue:2Pages:105-109
AbstractObjective: To study the effect of active compound 6F and A from Pteris semipinnata L.(PsL) on the activities of DNA topoisomerase (TOPO) I and II, activities of cytosolic and membrane TPK, and expression of oncogene c-myc in lung adenocarcinoma cells. Methods: The effect of compound 6F and A on activities of cytosolic and membrane TPK was measured by scintillation counting; the effect of compound A on expression of oncogene c-myc was determined by flow cytometry indirect fluorimetry. Results: compound 6F and A could inhibit the activities of TOPO I, and they strongly inhibited the TOPO II in 0.01 mg/L and 10.0 mg/L respectively. Compound A slightly inhibited the activities of membrane TPK, but not the cytosolic one. Compound A could inhibit the expression of oncogene c-myc. Conclusion: Topoisomerases are target of compound 6F and A. Compound A could slightly inhibit the activities of TPK, and showed an inhibitory effect on the expression of oncogene c-myc.
KeywordC-myc DNA topoisomerase Pteris semipinnata L. Tyrosine protein kinase
DOI10.1007/s11670-001-0025-9
URLView the original
Language英語
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Document TypeJournal article
CollectionUniversity of Macau
AffiliationGuangdong Medical University
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GB/T 7714
Li J.-H.,Liang N.-C.,Mo L.-E.,et al. Effect of active compounds isolated from Pteris semipinnata L on DNA topoisomerases and tyrosine protein kinase and expression of c-myc in lung adenocarcinoma cells[J]. Chinese Journal of Cancer Research,2001,13(2):105-109.
APA Li J.-H.,Liang N.-C.,Mo L.-E.,Zhang X.,&He C.-W..(2001).Effect of active compounds isolated from Pteris semipinnata L on DNA topoisomerases and tyrosine protein kinase and expression of c-myc in lung adenocarcinoma cells.Chinese Journal of Cancer Research,13(2),105-109.
MLA Li J.-H.,et al."Effect of active compounds isolated from Pteris semipinnata L on DNA topoisomerases and tyrosine protein kinase and expression of c-myc in lung adenocarcinoma cells".Chinese Journal of Cancer Research 13.2(2001):105-109.
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