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A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
Chen, Shao-Ru; Dai, Yan; Zhao, Jing; Lin, Ligen; Wang, Yitao; Wang, Ying
2018-02-14
Source PublicationFRONTIERS IN PHARMACOLOGY
ISSN1663-9812
Volume9
Abstract

Triptolide and celastrol are predominantly active natural products isolated from the medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar pharmacological activities, including anti-cancer, anti-inflammation, anti-obesity, and anti-diabetic activities. Triptolide and celastrol also provide neuroprotection and prevent cardiovascular and metabolic diseases. However, toxicity restricts the further development of triptolide and celastrol. In this review, we comprehensively review therapeutic targets and mechanisms of action, and translational study of triptolide and celastrol. We systemically discuss the structure-activity-relationship of triptolide, celastrol, and their derivatives. Furthermore, we propose the use of structural derivatives, targeted therapy, and combination treatment as possible solutions to reduce toxicity and increase therapeutic window of these potent natural products from T. wilfordii Hook F.

KeywordTripterygium Wilfordii Hook f Triptolide Celastrol Mechanisms Of Action Structure-activity-relationship
DOIhttp://doi.org/10.3389/fphar.2018.00104
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000425137100002
PublisherFRONTIERS MEDIA SA
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:23   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Yitao; Wang, Ying
AffiliationState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen, Shao-Ru,Dai, Yan,Zhao, Jing,et al. A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F[J]. FRONTIERS IN PHARMACOLOGY,2018,9.
APA Chen, Shao-Ru,Dai, Yan,Zhao, Jing,Lin, Ligen,Wang, Yitao,&Wang, Ying.(2018).A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F.FRONTIERS IN PHARMACOLOGY,9.
MLA Chen, Shao-Ru,et al."A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F".FRONTIERS IN PHARMACOLOGY 9(2018).
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