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Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-α-induced endothelial adhesion molecule expression and monocyte adhesion
Wan J.-B.1; Lee S.M.-Y.2; Wang J.-D.1; Wang N.2; He C.-W.1; Wang Y.-T.2; Kang J.X.1
2009-08-12
Source PublicationJournal of Agricultural and Food Chemistry
ISSN00218561
Volume57Issue:15Pages:6692-6697
AbstractIt is widely recognized that atherogenesis is associated with vascular inflammation. Panax notoginseng, a commonly used herb in China, has been shown to possess anti-inflammatory activity. In the present study, the antiatherogenic effect of P. notoginseng saponins (PNS) was examined in apolipoprotein E (apoE)-deficient mice. The molecular mechanisms responsible for the antivascular inflammatory effect of PNS on human coronary artery endothelial cells (HCAECs) were also investigated in vitro. PNS, dissolved in drinking water, was administered orally to two treatment groups at dosages of 4.0 and 12.0 mg/day/mouse, respectively. After 8 weeks, atherosclerosis in the entire aortic area was assessed using an en face method. Compared with the control group, both low- and high-dose PNS-treated groups showed a significant decrease in extent of atherosclerotic lesions by 61.4 and 66.2%, respectively (P < 0.01). PNS also notably reduced serum lipid levels. Serum levels of IL-6 and TNF-a in all groups of apoE-deficient mice were below the detection limit. In vitro studies showed that PNS dose-dependently inhibited monocyte adhesion on activated endothelium, as well as the expression of TNF-α-induced endothelial adhesion molecules, such as ICAM-1 and VCAM-1. In conclusion, PNS has antiatherogenic activity through, at least in part, its lipid-lowering and antivascular inflammatory mechanisms. © 2009 American Chemical Society.
KeywordAdhesion molecules ApoE-deficient mice Atherosclerosis Inflammation Panax notoginseng
DOI10.1021/jf900529w
URLView the original
Language英語
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Cited Times [WOS]:50   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Massachusetts General Hospital
2.Universidade de Macau
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GB/T 7714
Wan J.-B.,Lee S.M.-Y.,Wang J.-D.,et al. Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-α-induced endothelial adhesion molecule expression and monocyte adhesion[J]. Journal of Agricultural and Food Chemistry,2009,57(15):6692-6697.
APA Wan J.-B..,Lee S.M.-Y..,Wang J.-D..,Wang N..,He C.-W..,...&Kang J.X..(2009).Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-α-induced endothelial adhesion molecule expression and monocyte adhesion.Journal of Agricultural and Food Chemistry,57(15),6692-6697.
MLA Wan J.-B.,et al."Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-α-induced endothelial adhesion molecule expression and monocyte adhesion".Journal of Agricultural and Food Chemistry 57.15(2009):6692-6697.
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